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PHD1 regulates p53-mediated colorectal cancer chemoresistance.
Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M. Deschoemaeker S, et al. Among authors: mazzone m. EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492. EMBO Mol Med. 2015. PMID: 26290450 Free PMC article.
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P. Aragonés J, et al. Among authors: mazzone m. Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6. Nat Genet. 2008. PMID: 18176562 Free article.
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Schneider M, Van Geyte K, Fraisl P, Kiss J, Aragonés J, Mazzone M, Mairbäurl H, De Bock K, Jeoung NH, Mollenhauer M, Georgiadou M, Bishop T, Roncal C, Sutherland A, Jordan B, Gallez B, Weitz J, Harris RA, Maxwell P, Baes M, Ratcliffe P, Carmeliet P. Schneider M, et al. Among authors: mazzone m. Gastroenterology. 2010 Mar;138(3):1143-54.e1-2. doi: 10.1053/j.gastro.2009.09.057. Epub 2009 Oct 8. Gastroenterology. 2010. PMID: 19818783 Free article.
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.
Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, Jordan BF, Alitalo K, Maxwell P, Gallez B, Zhuang ZW, Saito Y, Simons M, De Palma M, Mazzone M. Takeda Y, et al. Among authors: mazzone m. Nature. 2011 Oct 9;479(7371):122-6. doi: 10.1038/nature10507. Nature. 2011. PMID: 21983962 Free PMC article.
Overcoming resistance to antiangiogenic therapies.
Tejpar S, Prenen H, Mazzone M. Tejpar S, et al. Among authors: mazzone m. Oncologist. 2012;17(8):1039-50. doi: 10.1634/theoncologist.2012-0068. Epub 2012 Jul 6. Oncologist. 2012. PMID: 22773560 Free PMC article. Review.
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.
Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M. Kiss J, et al. Among authors: mazzone m. J Immunol. 2012 Aug 15;189(4):1955-65. doi: 10.4049/jimmunol.1103471. Epub 2012 Jul 11. J Immunol. 2012. PMID: 22786772 Free PMC article.
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity.
Leite de Oliveira R, Deschoemaeker S, Henze AT, Debackere K, Finisguerra V, Takeda Y, Roncal C, Dettori D, Tack E, Jönsson Y, Veschini L, Peeters A, Anisimov A, Hofmann M, Alitalo K, Baes M, D'hooge J, Carmeliet P, Mazzone M. Leite de Oliveira R, et al. Among authors: mazzone m. Cancer Cell. 2012 Aug 14;22(2):263-77. doi: 10.1016/j.ccr.2012.06.028. Cancer Cell. 2012. PMID: 22897855 Free article.
PHD2 regulates arteriogenic macrophages through TIE2 signalling.
Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M. Hamm A, et al. Among authors: mazzone m. EMBO Mol Med. 2013 Jun;5(6):843-57. doi: 10.1002/emmm.201302695. Epub 2013 Apr 25. EMBO Mol Med. 2013. PMID: 23616286 Free PMC article.
282 results