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Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.
Virgilio A, Petraccone L, Vellecco V, Bucci M, Varra M, Irace C, Santamaria R, Pepe A, Mayol L, Esposito V, Galeone A. Virgilio A, et al. Among authors: mayol l. Nucleic Acids Res. 2015 Dec 15;43(22):10602-11. doi: 10.1093/nar/gkv1224. Epub 2015 Nov 17. Nucleic Acids Res. 2015. PMID: 26582916 Free PMC article.
Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities.
Rivieccio E, Tartaglione L, Esposito V, Dell'Aversano C, Koneru PC, Scuotto M, Virgilio A, Mayol L, Kvaratskhelia M, Varra M. Rivieccio E, et al. Among authors: mayol l. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):351-361. doi: 10.1016/j.bbagen.2018.11.001. Epub 2018 Nov 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30414444
PNA-DNA chimeras forming quadruplex structures.
Esposito V, Galeone A, Mayol L, Messere A, Piccialli G, Randazzo A. Esposito V, et al. Among authors: mayol l. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1681-4. doi: 10.1081/NCN-120023112. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565494
183 results