Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism.
Wood J, Abdelrazig S, Evseev S, Ortori C, Castellanos-Uribe M, May ST, Barrett DA, Diksin M, Chakraborty S, Kim DH, Grundy RG, Rahman R.
Wood J, et al. Among authors: may st.
Cancers (Basel). 2022 Aug 11;14(16):3873. doi: 10.3390/cancers14163873.
Cancers (Basel). 2022.
PMID: 36010867
Free PMC article.
Cholesterol is an integral component of cell membranes and is required by cancer cells to maintain growth and may also drive transformation. Here, we show that removal of exogenous cholesterol in the form of lipoproteins from culture medium was detrimental to the growth of …
Cholesterol is an integral component of cell membranes and is required by cancer cells to maintain growth and may also drive transfor …