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Rational Design and Synthesis of AT1R Antagonists.
Georgiou N, Gkalpinos VK, Katsakos SD, Vassiliou S, Tzakos AG, Mavromoustakos T. Georgiou N, et al. Among authors: mavromoustakos t. Molecules. 2021 May 14;26(10):2927. doi: 10.3390/molecules26102927. Molecules. 2021. PMID: 34069122 Free PMC article. Review.
Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J. Roumelioti P, et al. Among authors: mavromoustakos t. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2. Bioorg Med Chem Lett. 2002. PMID: 12182875
Conformational and biological studies for a pair of novel synthetic AT1 antagonists: stereoelectronic requirements for antihypertensive efficacy.
Zoumpoulakis P, Zoga A, Roumelioti P, Giatas N, Grdadolnik SG, Iliodromitis E, Vlahakos D, Kremastinos D, Matsoukas JM, Mavromoustakos T. Zoumpoulakis P, et al. Among authors: mavromoustakos t. J Pharm Biomed Anal. 2003 Apr 1;31(5):833-44. doi: 10.1016/s0731-7085(02)00655-6. J Pharm Biomed Anal. 2003. PMID: 12684096
Design and synthesis of novel antihypertensive drugs.
Moutevelis-Minakakis P, Gianni M, Stougiannou H, Zoumpoulakis P, Zoga A, Vlahakos AD, Iliodromitis E, Mavromoustakos T. Moutevelis-Minakakis P, et al. Among authors: mavromoustakos t. Bioorg Med Chem Lett. 2003 May 19;13(10):1737-40. doi: 10.1016/s0960-894x(03)00251-8. Bioorg Med Chem Lett. 2003. PMID: 12729654
Synthesis of new optically active 2-pyrrolidinones.
Moutevelis-Minakakis P, Papavassilopoulou E, Mavromoustakos T. Moutevelis-Minakakis P, et al. Among authors: mavromoustakos t. Molecules. 2012 Dec 21;18(1):50-73. doi: 10.3390/molecules18010050. Molecules. 2012. PMID: 23344188 Free PMC article.
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: mavromoustakos t. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers.
Agelis G, Kelaidonis K, Resvani A, Kalavrizioti D, Androutsou ME, Plotas P, Vlahakos D, Koukoulitsa C, Tselios T, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: mavromoustakos t. Molecules. 2013 Jun 27;18(7):7510-32. doi: 10.3390/molecules18077510. Molecules. 2013. PMID: 23807577 Free PMC article.
AT1 antagonists: a patent review (2008 - 2012).
Mavromoustakos T, Agelis G, Durdagi S. Mavromoustakos T, et al. Expert Opin Ther Pat. 2013 Nov;23(11):1483-94. doi: 10.1517/13543776.2013.830104. Epub 2013 Aug 23. Expert Opin Ther Pat. 2013. PMID: 23968548 Review.
243 results