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Design, synthesis and biological evaluation of cyclic angiotensin II analogues with 3,5 side-chain bridges. Role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists.
Roumelioti P, Polevaya L, Zoumpoulakis P, Giatas N, Mutule I, Keivish T, Zoga A, Vlahakos D, Iliodromitis E, Kremastinos D, Grdadolnik SG, Mavromoustakos T, Matsoukas J. Roumelioti P, et al. Among authors: mavromoustakos t. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2627-33. doi: 10.1016/s0960-894x(02)00474-2. Bioorg Med Chem Lett. 2002. PMID: 12182875
Losartan's molecular basis of interaction with membranes and AT1 receptor.
Zoumpoulakis P, Daliani I, Zervou M, Kyrikou I, Siapi E, Lamprinidis G, Mikros E, Mavromoustakos T. Zoumpoulakis P, et al. Among authors: mavromoustakos t. Chem Phys Lipids. 2003 Sep;125(1):13-25. doi: 10.1016/s0009-3084(03)00053-7. Chem Phys Lipids. 2003. PMID: 14625072
Effects of non-steroid anti-inflammatory drugs in membrane bilayers.
Kyrikou I, Hadjikakou SK, Kovala-Demertzi D, Viras K, Mavromoustakos T. Kyrikou I, et al. Among authors: mavromoustakos t. Chem Phys Lipids. 2004 Dec;132(2):157-69. doi: 10.1016/j.chemphyslip.2004.06.005. Chem Phys Lipids. 2004. PMID: 15555602
Antihypertensive drug valsartan in solution and at the AT1 receptor: conformational analysis, dynamic NMR spectroscopy, in silico docking, and molecular dynamics simulations.
Potamitis C, Zervou M, Katsiaras V, Zoumpoulakis P, Durdagi S, Papadopoulos MG, Hayes JM, Grdadolnik SG, Kyrikou I, Argyropoulos D, Vatougia G, Mavromoustakos T. Potamitis C, et al. Among authors: mavromoustakos t. J Chem Inf Model. 2009 Mar;49(3):726-39. doi: 10.1021/ci800427s. J Chem Inf Model. 2009. PMID: 19256500
Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
Politi AP, Zervou MV, Triantafyllidi H, Zoumpoulakis PG, Mavromoustakos TM, Zoga AA, Moutevelis-Minakakis P, Kokotos G, Iliodromitis EK, Kremastinos DT. Politi AP, et al. J Renin Angiotensin Aldosterone Syst. 2010 Jun;11(2):103-10. doi: 10.1177/1470320310365016. Epub 2010 Mar 31. J Renin Angiotensin Aldosterone Syst. 2010. PMID: 20357048 Free article.
243 results