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High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex.
Zhou X, Besse A, Peter J, Steinhardt MJ, Vogt C, Nerreter S, Teufel E, Stanojkovska E, Xiao X, Hornburger H, Haertle L, Lopez MM, Munawar U, Riedel A, Han S, Maurits E, Overkleeft HS, Florea B, Einsele H, Kortüm KM, Driessen C, Besse L, Rasche L. Zhou X, et al. Among authors: maurits e. Haematologica. 2023 Jun 1;108(6):1628-1639. doi: 10.3324/haematol.2022.282225. Haematologica. 2023. PMID: 36727403 Free PMC article.
Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics.
de Geus MAR, Maurits E, Sarris AJC, Hansen T, Kloet MS, Kamphorst K, Ten Hoeve W, Robillard MS, Pannwitz A, Bonnet SA, Codée JDC, Filippov DV, Overkleeft HS, van Kasteren SI. de Geus MAR, et al. Among authors: maurits e. Chemistry. 2020 Aug 6;26(44):9900-9904. doi: 10.1002/chem.201905446. Epub 2020 Jun 3. Chemistry. 2020. PMID: 32154603 Free PMC article.
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits.
Xin BT, Huber EM, de Bruin G, Heinemeyer W, Maurits E, Espinal C, Du Y, Janssens M, Weyburne ES, Kisselev AF, Florea BI, Driessen C, van der Marel GA, Groll M, Overkleeft HS. Xin BT, et al. Among authors: maurits e. J Med Chem. 2019 Feb 14;62(3):1626-1642. doi: 10.1021/acs.jmedchem.8b01884. Epub 2019 Feb 5. J Med Chem. 2019. PMID: 30657666 Free PMC article.
23 results