Maurer TS - Search Results

1

Unbound Brain-to-Plasma Partition Coefficient, K_p,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development.

Loryan I, Reichel A, Feng B, Bundgaard C, Shaffer C, Kalvass C, Bednarczyk D, Morrison D, Lesuisse D, Hoppe E, Terstappen GC, Fischer H, Di L, Colclough N, Summerfield S, Buckley ST, Maurer TS, Fridén M. Loryan I, et al. Among authors: maurer ts. Pharm Res. 2022 Jul;39(7):1321-1341. doi: 10.1007/s11095-022-03246-6. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411506 Free PMC article.

2

Impact of recovery on fraction unbound using equilibrium dialysis.

Di L, Umland JP, Trapa PE, Maurer TS. Di L, et al. Among authors: maurer ts. J Pharm Sci. 2012 Mar;101(3):1327-35. doi: 10.1002/jps.23013. Epub 2011 Dec 9. J Pharm Sci. 2012. PMID: 22161810

3

Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.

Ghosh A, Maurer TS, Litchfield J, Varma MV, Rotter C, Scialis R, Feng B, Tu M, Guimaraes CR, Scott DO. Ghosh A, et al. Among authors: maurer ts. Drug Metab Dispos. 2014 Oct;42(10):1599-610. doi: 10.1124/dmd.114.058032. Epub 2014 Jul 14. Drug Metab Dispos. 2014. PMID: 25024402

4

Volume of Distribution in Drug Design.

Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. Among authors: maurer ts. J Med Chem. 2015 Aug 13;58(15):5691-8. doi: 10.1021/acs.jmedchem.5b00201. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25799158

5

Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System.

El-Kattan AF, Varma MV, Steyn SJ, Scott DO, Maurer TS, Bergman A. El-Kattan AF, et al. Among authors: maurer ts. Pharm Res. 2016 Dec;33(12):3021-3030. doi: 10.1007/s11095-016-2024-z. Epub 2016 Sep 12. Pharm Res. 2016. PMID: 27620173

6

Passive drug permeation through membranes and cellular distribution.

Scott DO, Ghosh A, Di L, Maurer TS. Scott DO, et al. Among authors: maurer ts. Pharmacol Res. 2017 Mar;117:94-102. doi: 10.1016/j.phrs.2016.11.028. Epub 2016 Nov 24. Pharmacol Res. 2017. PMID: 27890815 Review.

7

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM. Varma MV, et al. Among authors: maurer ts. Clin Pharmacol Ther. 2017 Jul;102(1):33-36. doi: 10.1002/cpt.595. Epub 2017 Feb 3. Clin Pharmacol Ther. 2017. PMID: 27984654 No abstract available.

8

In Vitro-In Vivo Extrapolation of Intestinal Availability for Carboxylesterase Substrates Using Portal Vein-Cannulated Monkey.

Trapa PE, Beaumont K, Atkinson K, Eng H, King-Ahmad A, Scott DO, Maurer TS, Di L. Trapa PE, et al. Among authors: maurer ts. J Pharm Sci. 2017 Mar;106(3):898-905. doi: 10.1016/j.xphs.2016.12.001. Epub 2016 Dec 18. J Pharm Sci. 2017. PMID: 27998705

9

Relevance of Half-Life in Drug Design.

Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. Among authors: maurer ts. J Med Chem. 2018 May 24;61(10):4273-4282. doi: 10.1021/acs.jmedchem.7b00969. Epub 2017 Nov 17. J Med Chem. 2018. PMID: 29112446

10

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.

Li R, Niosi M, Johnson N, Tess DA, Kimoto E, Lin J, Yang X, Riccardi KA, Ryu S, El-Kattan AF, Maurer TS, Tremaine LM, Di L. Li R, et al. Among authors: maurer ts. Drug Metab Dispos. 2018 Apr;46(4):346-356. doi: 10.1124/dmd.117.078790. Epub 2018 Jan 12. Drug Metab Dispos. 2018. PMID: 29330218

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