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The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL. Maurer MF, et al. Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5. Nat Commun. 2022. PMID: 35379805 Free PMC article.
Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA. Dillon SR, et al. Nat Immunol. 2004 Jul;5(7):752-60. doi: 10.1038/ni1084. Epub 2004 Jun 6. Nat Immunol. 2004. PMID: 15184896
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.
Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D. Parrish-Novak J, et al. Nature. 2000 Nov 2;408(6808):57-63. doi: 10.1038/35040504. Nature. 2000. PMID: 11081504
Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.
Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC, Hamacher NB, Rixon MW, Dillon SR. Lewis KE, et al. Among authors: maurer mf. J Eur Acad Dermatol Venereol. 2017 Jan;31(1):142-150. doi: 10.1111/jdv.13794. Epub 2016 Aug 8. J Eur Acad Dermatol Venereol. 2017. PMID: 27501029
B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin.
Dillon SR, Harder B, Lewis KB, Moore MD, Liu H, Bukowski TR, Hamacher NB, Lantry MM, Maurer M, Krejsa CM, Ellsworth JL, Pederson S, Elkon KB, Wener MH, Dall'Era M, Gross JA. Dillon SR, et al. Arthritis Res Ther. 2010;12(2):R48. doi: 10.1186/ar2959. Epub 2010 Mar 19. Arthritis Res Ther. 2010. PMID: 20302641 Free PMC article.
Cloning and gene expression of a novel human ribonucleoprotein.
Conklin DC, Rixon MW, Kuestner RE, Maurer MF, Whitmore TE, Millar RP. Conklin DC, et al. Among authors: maurer mf. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):465-9. doi: 10.1016/s0167-4781(00)00090-7. Biochim Biophys Acta. 2000. PMID: 11004516
The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping.
Whitmore TE, Maurer MF, Day HL, Jelmberg AC, Dasovich MM, Sundborg LM, Burkhead SK, Heipel MD, Madden KL, Kramer JM, Kuijper JL, Xu WF, Jaspers SR, Holly RD, Lok S. Whitmore TE, et al. Among authors: maurer mf. Cytogenet Cell Genet. 1999;87(1-2):93-4. doi: 10.1159/000015400. Cytogenet Cell Genet. 1999. PMID: 10640820 No abstract available.
A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist.
Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, Dillon SR, Gao Z, Gilbert T, Madden K, Schlutsmeyer S, Yao L, Whitmore TE, Chandrasekher Y, Grant FJ, Maurer M, Jelinek L, Storey H, Brender T, Hammond A, Topouzis S, Clegg CH, Foster DC. Xu W, et al. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9511-6. doi: 10.1073/pnas.171303198. Epub 2001 Jul 31. Proc Natl Acad Sci U S A. 2001. PMID: 11481447 Free PMC article.
17 results