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The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.
Front Pharmacol. 2020 Sep 3;11:1297. doi: 10.3389/fphar.2020.01297. eCollection 2020.
Front Pharmacol. 2020.
PMID: 33013366
Free PMC article.
Review.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.
Maucher IV, Rühl M, Kretschmer SB, Hofmann B, Kühn B, Fettel J, Vogel A, Flügel KT, Manolikakes G, Hellmuth N, Häfner AK, Golghalyani V, Ball AK, Piesche M, Matrone C, Geisslinger G, Parnham MJ, Karas M, Steinhilber D, Roos J, Maier TJ.
Maucher IV, et al.
Biochem Pharmacol. 2017 Feb 1;125:55-74. doi: 10.1016/j.bcp.2016.11.004. Epub 2016 Nov 4.
Biochem Pharmacol. 2017.
PMID: 27823964
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Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.
Kühn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, Rühl M, Kühn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ.
Kühn B, et al. Among authors: maucher iv.
Biochem Pharmacol. 2018 Sep;155:48-60. doi: 10.1016/j.bcp.2018.06.014. Epub 2018 Jun 15.
Biochem Pharmacol. 2018.
PMID: 29909078
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Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ.
Roos J, et al. Among authors: maucher iv.
Antioxid Redox Signal. 2018 May 10;28(14):1265-1285. doi: 10.1089/ars.2017.7155. Epub 2017 Sep 8.
Antioxid Redox Signal. 2018.
PMID: 28699354
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Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Roos J, Grösch S, Werz O, Schröder P, Ziegler S, Fulda S, Paulus P, Urbschat A, Kühn B, Maucher I, Fettel J, Vorup-Jensen T, Piesche M, Matrone C, Steinhilber D, Parnham MJ, Maier TJ.
Roos J, et al.
Pharmacol Ther. 2016 Jan;157:43-64. doi: 10.1016/j.pharmthera.2015.11.001. Epub 2015 Nov 6.
Pharmacol Ther. 2016.
PMID: 26549540
Review.
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Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles.
Kretschmer SB, Woltersdorf S, Vogt D, Lillich FF, Rühl M, Karas M, Maucher IV, Roos J, Häfner AK, Kaiser A, Wurglics M, Schubert-Zsilavecz M, Angioni C, Geisslinger G, Stark H, Steinhilber D, Hofmann B.
Kretschmer SB, et al. Among authors: maucher iv.
Biochem Pharmacol. 2017 Jan 1;123:52-62. doi: 10.1016/j.bcp.2016.09.021. Epub 2016 Sep 23.
Biochem Pharmacol. 2017.
PMID: 27671344
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