Matts R - Search Results

1

Structure-Activity Relationship Study of Tertiary Alcohol Hsp90α-Selective Inhibitors with Novel Binding Mode.

Mishra SJ, Reynolds TS, Merfeld T, Balch M, Peng S, Deng J, Matts R, Blagg BSJ. Mishra SJ, et al. Among authors: matts r. ACS Med Chem Lett. 2022 Nov 4;13(12):1870-1878. doi: 10.1021/acsmedchemlett.2c00327. eCollection 2022 Dec 8. ACS Med Chem Lett. 2022. PMID: 36518703 Free PMC article.

2

High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.

Galam L, Hadden MK, Ma Z, Ye QZ, Yun BG, Blagg BS, Matts RL. Galam L, et al. Bioorg Med Chem. 2007 Mar 1;15(5):1939-46. doi: 10.1016/j.bmc.2007.01.004. Epub 2007 Jan 4. Bioorg Med Chem. 2007. PMID: 17223347 Free PMC article.

3

Derrubone, an inhibitor of the Hsp90 protein folding machinery.

Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS. Hadden MK, et al. J Nat Prod. 2007 Dec;70(12):2014-8. doi: 10.1021/np070190s. Epub 2007 Nov 17. J Nat Prod. 2007. PMID: 18020309

4

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.

Hadden MK, Hill SA, Davenport J, Matts RL, Blagg BS. Hadden MK, et al. Bioorg Med Chem. 2009 Jan 15;17(2):634-40. doi: 10.1016/j.bmc.2008.11.064. Epub 2008 Dec 3. Bioorg Med Chem. 2009. PMID: 19101151 Free PMC article.

5

Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.

Matthews SB, Vielhauer GA, Manthe CA, Chaguturu VK, Szabla K, Matts RL, Donnelly AC, Blagg BS, Holzbeierlein JM. Matthews SB, et al. Prostate. 2010 Jan 1;70(1):27-36. doi: 10.1002/pros.21035. Prostate. 2010. PMID: 19739131 Free PMC article.

6

KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.

Shelton SN, Shawgo ME, Matthews SB, Lu Y, Donnelly AC, Szabla K, Tanol M, Vielhauer GA, Rajewski RA, Matts RL, Blagg BS, Robertson JD. Shelton SN, et al. Mol Pharmacol. 2009 Dec;76(6):1314-22. doi: 10.1124/mol.109.058545. Epub 2009 Sep 9. Mol Pharmacol. 2009. PMID: 19741006 Free PMC article.

7

Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action.

Matts RL, Manjarrez JR. Matts RL, et al. Curr Top Med Chem. 2009;9(15):1462-78. doi: 10.2174/156802609789895692. Curr Top Med Chem. 2009. PMID: 19860729 Review.

8

A systematic protocol for the characterization of Hsp90 modulators.

Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. Matts RL, et al. Bioorg Med Chem. 2011 Jan 1;19(1):684-92. doi: 10.1016/j.bmc.2010.10.029. Epub 2010 Oct 19. Bioorg Med Chem. 2011. PMID: 21129982 Free PMC article.

9

Identification and initial SAR of silybin: an Hsp90 inhibitor.

Zhao H, Brandt GE, Galam L, Matts RL, Blagg BS. Zhao H, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2659-64. doi: 10.1016/j.bmcl.2010.12.088. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21273068

10

Gambogic acid, a natural product inhibitor of Hsp90.

Davenport J, Manjarrez JR, Peterson L, Krumm B, Blagg BS, Matts RL. Davenport J, et al. Among authors: matts rl. J Nat Prod. 2011 May 27;74(5):1085-92. doi: 10.1021/np200029q. Epub 2011 Apr 12. J Nat Prod. 2011. PMID: 21486005 Free PMC article.

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