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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Brown AJH, Bradley SJ, Marshall FH, Brown GA, Bennett KA, Brown J, Cansfield JE, Cross DM, de Graaf C, Hudson BD, Dwomoh L, Dias JM, Errey JC, Hurrell E, Liptrot J, Mattedi G, Molloy C, Nathan PJ, Okrasa K, Osborne G, Patel JC, Pickworth M, Robertson N, Shahabi S, Bundgaard C, Phillips K, Broad LM, Goonawardena AV, Morairty SR, Browning M, Perini F, Dawson GR, Deakin JFW, Smith RT, Sexton PM, Warneck J, Vinson M, Tasker T, Tehan BG, Teobald B, Christopoulos A, Langmead CJ, Jazayeri A, Cooke RM, Rucktooa P, Congreve MS, Weir M, Tobin AB. Brown AJH, et al. Among authors: mattedi g. Cell. 2021 Nov 24;184(24):5886-5901.e22. doi: 10.1016/j.cell.2021.11.001. Cell. 2021. PMID: 34822784 Free article. Clinical Trial.
A combined activation mechanism for the glucagon receptor.
Mattedi G, Acosta-Gutiérrez S, Clark T, Gervasio FL. Mattedi G, et al. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15414-15422. doi: 10.1073/pnas.1921851117. Epub 2020 Jun 22. Proc Natl Acad Sci U S A. 2020. PMID: 32571939 Free PMC article.
Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication.
Spizzichino S, Mattedi G, Lauder K, Valle C, Aouadi W, Canard B, Decroly E, Kaptein SJF, Neyts J, Graham C, Sule Z, Barlow DJ, Silvestri R, Castagnolo D. Spizzichino S, et al. Among authors: mattedi g. ChemMedChem. 2020 Feb 17;15(4):385-390. doi: 10.1002/cmdc.201900533. Epub 2020 Jan 7. ChemMedChem. 2020. PMID: 31805205 Free PMC article.