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Fatty acid elongation by ELOVL6 hampers remyelination by promoting inflammatory foam cell formation during demyelination.
Garcia Corrales AV, Verberk SGS, Haidar M, Grajchen E, Dehairs J, Vanherle S, Loix M, Weytjens T, Gervois P, Matsuzaka T, Lambrichts I, Swinnen JV, Bogie JFJ, Hendriks JJA. Garcia Corrales AV, et al. Among authors: matsuzaka t. Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2301030120. doi: 10.1073/pnas.2301030120. Epub 2023 Sep 5. Proc Natl Acad Sci U S A. 2023. PMID: 37669365 Free PMC article.
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Saito R, et al. Among authors: matsuzaka t. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. doi: 10.1161/ATVBAHA.110.221663. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817094
Elovl6 promotes nonalcoholic steatohepatitis.
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H. Matsuzaka T, et al. Hepatology. 2012 Dec;56(6):2199-208. doi: 10.1002/hep.25932. Hepatology. 2012. PMID: 22753171
Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.
Kuba M, Matsuzaka T, Matsumori R, Saito R, Kaga N, Taka H, Ikehata K, Okada N, Kikuchi T, Ohno H, Han SI, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Suzuki H, Sone H, Yahagi N, Arakawa Y, Fujimura T, Nakagawa Y, Yamada N, Shimano H. Kuba M, et al. Among authors: matsuzaka t. Sci Rep. 2015 Dec 1;5:17604. doi: 10.1038/srep17604. Sci Rep. 2015. PMID: 26619823 Free PMC article.
Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase/Krüppel-Like Factor 4 (AMPK/KLF4) Signaling.
Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. Sunaga H, et al. Among authors: matsuzaka t. J Am Heart Assoc. 2016 Nov 23;5(12):e004014. doi: 10.1161/JAHA.116.004014. J Am Heart Assoc. 2016. PMID: 27881420 Free PMC article.
178 results