Matricon P - Search Results

1

Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology.

Kampen S, Duy Vo D, Zhang X, Panel N, Yang Y, Jaiteh M, Matricon P, Svenningsson P, Brea J, Loza MI, Kihlberg J, Carlsson J. Kampen S, et al. Among authors: matricon p. Angew Chem Int Ed Engl. 2021 Aug 9;60(33):18022-18030. doi: 10.1002/anie.202101478. Epub 2021 Jul 16. Angew Chem Int Ed Engl. 2021. PMID: 33904641 Free PMC article.

2

The tyrosine Y250^2.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

Strakova K, Matricon P, Yokota C, Arthofer E, Bernatik O, Rodriguez D, Arenas E, Carlsson J, Bryja V, Schulte G. Strakova K, et al. Among authors: matricon p. Cell Signal. 2017 Oct;38:85-96. doi: 10.1016/j.cellsig.2017.06.018. Epub 2017 Jun 29. Cell Signal. 2017. PMID: 28668722

3

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A _2A adenosine receptor binding site.

Matricon P, Ranganathan A, Warnick E, Gao ZG, Rudling A, Lambertucci C, Marucci G, Ezzati A, Jaiteh M, Dal Ben D, Jacobson KA, Carlsson J. Matricon P, et al. Sci Rep. 2017 Jul 25;7(1):6398. doi: 10.1038/s41598-017-04905-0. Sci Rep. 2017. PMID: 28743961 Free PMC article.

4

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.

Petersen J, Wright SC, Rodríguez D, Matricon P, Lahav N, Vromen A, Friedler A, Strömqvist J, Wennmalm S, Carlsson J, Schulte G. Petersen J, et al. Among authors: matricon p. Nat Commun. 2017 Aug 9;8(1):226. doi: 10.1038/s41467-017-00253-9. Nat Commun. 2017. PMID: 28790300 Free PMC article.

5

FZD₅ is a Gα_q-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, Simon K, Le Gouill C, Matricon P, Namkung Y, Lukasheva V, König GM, Laporte SA, Carlsson J, Kostenis E, Bouvier M, Schulte G, Hoffmann C. Wright SC, et al. Among authors: matricon p. Sci Signal. 2018 Dec 4;11(559):eaar5536. doi: 10.1126/scisignal.aar5536. Sci Signal. 2018. PMID: 30514810

6

Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches.

Fleetwood O, Matricon P, Carlsson J, Delemotte L. Fleetwood O, et al. Among authors: matricon p. Biochemistry. 2020 Feb 25;59(7):880-891. doi: 10.1021/acs.biochem.9b00842. Epub 2020 Feb 7. Biochemistry. 2020. PMID: 31999436 Free PMC article.

7

Adenosine A_2A receptor antagonists: from caffeine to selective non-xanthines.

Jacobson KA, Gao ZG, Matricon P, Eddy MT, Carlsson J. Jacobson KA, et al. Among authors: matricon p. Br J Pharmacol. 2022 Jul;179(14):3496-3511. doi: 10.1111/bph.15103. Epub 2020 Jun 19. Br J Pharmacol. 2022. PMID: 32424811 Free PMC article. Review.

8

Ligand design by targeting a binding site water.

Matricon P, Suresh RR, Gao ZG, Panel N, Jacobson KA, Carlsson J. Matricon P, et al. Chem Sci. 2020 Nov 19;12(3):960-968. doi: 10.1039/d0sc04938g. Chem Sci. 2020. PMID: 34163862 Free PMC article.

9

Fragment-based design of selective GPCR ligands guided by free energy simulations.

Matricon P, Vo DD, Gao ZG, Kihlberg J, Jacobson KA, Carlsson J. Matricon P, et al. Chem Commun (Camb). 2021 Nov 19;57(92):12305-12308. doi: 10.1039/d1cc03202j. Chem Commun (Camb). 2021. PMID: 34734588 Free PMC article.

10

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.

Begnini F, Geschwindner S, Johansson P, Wissler L, Lewis RJ, Danelius E, Luttens A, Matricon P, Carlsson J, Lenders S, König B, Friedel A, Sjö P, Schiesser S, Kihlberg J. Begnini F, et al. Among authors: matricon p. J Med Chem. 2022 Feb 24;65(4):3473-3517. doi: 10.1021/acs.jmedchem.1c01975. Epub 2022 Feb 2. J Med Chem. 2022. PMID: 35108001 Free PMC article.

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