Mathias N - Search Results

1

In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development.

Zane P, Gieschen H, Kersten E, Mathias N, Ollier C, Johansson P, Van den Bergh A, Van Hemelryck S, Reichel A, Rotgeri A, Schäfer K, Müllertz A, Langguth P. Zane P, et al. Among authors: mathias n. Eur J Pharm Biopharm. 2019 Sep;142:222-231. doi: 10.1016/j.ejpb.2019.06.010. Epub 2019 Jun 21. Eur J Pharm Biopharm. 2019. PMID: 31233862 Review.

2

Mitigation of Adverse Clinical Events of a Narrow Target Therapeutic Index Compound through Modified Release Formulation Design: An in Vitro, in Vivo, in Silico, and Clinical Pharmacokinetic Analysis.

Good DJ, Hartley R, Mathias N, Crison J, Tirucherai G, Timmins P, Hussain M, Haddadin R, Koo O, Nikfar F, Fung NK. Good DJ, et al. Among authors: mathias n. Mol Pharm. 2015 Dec 7;12(12):4434-44. doi: 10.1021/acs.molpharmaceut.5b00624. Epub 2015 Nov 4. Mol Pharm. 2015. PMID: 26536519 Clinical Trial.

3

Assessing the risk of pH-dependent absorption for new molecular entities: a novel in vitro dissolution test, physicochemical analysis, and risk assessment strategy.

Mathias NR, Xu Y, Patel D, Grass M, Caldwell B, Jager C, Mullin J, Hansen L, Crison J, Saari A, Gesenberg C, Morrison J, Vig B, Raghavan K. Mathias NR, et al. Mol Pharm. 2013 Nov 4;10(11):4063-73. doi: 10.1021/mp400426f. Epub 2013 Sep 26. Mol Pharm. 2013. PMID: 24032349

4

From bench to humans: formulation development of a poorly water soluble drug to mitigate food effect.

Pandey P, Hamey R, Bindra DS, Huang Z, Mathias N, Eley T, Crison J, Yan B, Perrone R, Vemavarapu C. Pandey P, et al. Among authors: mathias n. AAPS PharmSciTech. 2014 Apr;15(2):407-16. doi: 10.1208/s12249-013-0069-4. Epub 2014 Jan 18. AAPS PharmSciTech. 2014. PMID: 24442773 Free PMC article.

5

Food Effect in Humans: Predicting the Risk Through In Vitro Dissolution and In Vivo Pharmacokinetic Models.

Mathias N, Xu Y, Vig B, Kestur U, Saari A, Crison J, Desai D, Vanarase A, Hussain M. Mathias N, et al. AAPS J. 2015 Jul;17(4):988-98. doi: 10.1208/s12248-015-9759-z. Epub 2015 May 2. AAPS J. 2015. PMID: 25933598 Free PMC article.

6

Biopharmaceutical Evaluation and CMC Aspects of Oral Modified Release Formulations.

Chang RK, Mathias N, Hussain MA. Chang RK, et al. Among authors: mathias n. AAPS J. 2017 Sep;19(5):1348-1358. doi: 10.1208/s12248-017-0112-6. Epub 2017 Jul 5. AAPS J. 2017. PMID: 28681160

7

Pulmonary delivery of a GLP-1 receptor agonist, BMS-686117.

Qian F, Mathias N, Moench P, Chi C, Desikan S, Hussain M, Smith RL. Qian F, et al. Among authors: mathias n. Int J Pharm. 2009 Jan 21;366(1-2):218-20. doi: 10.1016/j.ijpharm.2008.10.020. Epub 2008 Nov 5. Int J Pharm. 2009. PMID: 19027057

8

Non-invasive systemic drug delivery: developability considerations for alternate routes of administration.

Mathias NR, Hussain MA. Mathias NR, et al. J Pharm Sci. 2010 Jan;99(1):1-20. doi: 10.1002/jps.21793. J Pharm Sci. 2010. PMID: 19499570 Review.

9

Solution behavior of PVP-VA and HPMC-AS-based amorphous solid dispersions and their bioavailability implications.

Qian F, Wang J, Hartley R, Tao J, Haddadin R, Mathias N, Hussain M. Qian F, et al. Among authors: mathias n. Pharm Res. 2012 Oct;29(10):2765-76. doi: 10.1007/s11095-012-0695-7. Pharm Res. 2012. PMID: 22315020

10

Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy.

Gesenberg C, Mathias NR, Xu Y, Crison J, Savant I, Saari A, Good DJ, Hemenway JN, Narang AS, Schartman RR, Zheng N, Buzescu A, Patel J. Gesenberg C, et al. Among authors: mathias nr. Pharm Res. 2019 Oct 21;36(12):164. doi: 10.1007/s11095-019-2698-0. Pharm Res. 2019. PMID: 31637544

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