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Migraine models.
Benemei S, De Cesaris F, Nicoletti P, Materazzi S, Nassini R, Geppetti P. Benemei S, et al. Among authors: materazzi s. Methods Mol Biol. 2010;617:105-14. doi: 10.1007/978-1-60327-323-7_9. Methods Mol Biol. 2010. PMID: 20336417
The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.
Benemei S, De Logu F, Li Puma S, Marone IM, Coppi E, Ugolini F, Liedtke W, Pollastro F, Appendino G, Geppetti P, Materazzi S, Nassini R. Benemei S, et al. Among authors: materazzi s. Br J Pharmacol. 2017 Sep;174(17):2897-2911. doi: 10.1111/bph.13917. Epub 2017 Jul 20. Br J Pharmacol. 2017. PMID: 28622417 Free PMC article.
The concept of neurogenic inflammation.
Geppetti P, Nassini R, Materazzi S, Benemei S. Geppetti P, et al. Among authors: materazzi s. BJU Int. 2008 Mar;101 Suppl 3:2-6. doi: 10.1111/j.1464-410X.2008.07493.x. BJU Int. 2008. PMID: 18307678 Review.
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Nassini R, Materazzi S, Vriens J, Prenen J, Benemei S, De Siena G, la Marca G, Andrè E, Preti D, Avonto C, Sadofsky L, Di Marzo V, De Petrocellis L, Dussor G, Porreca F, Taglialatela-Scafati O, Appendino G, Nilius B, Geppetti P. Nassini R, et al. Among authors: materazzi s. Brain. 2012 Feb;135(Pt 2):376-90. doi: 10.1093/brain/awr272. Epub 2011 Oct 27. Brain. 2012. PMID: 22036959
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
128 results