G13A substitution affects the biochemical and physical properties of the elongation factor 1 alpha. A reduced intrinsic GTPase activity is partially restored by kirromycin.
Masullo M, Cantiello P, de Paola B, Catanzano F, Arcari P, Bocchini V.
Masullo M, et al.
Biochemistry. 2002 Jan 15;41(2):628-33. doi: 10.1021/bi015598h.
Biochemistry. 2002.
PMID: 11781103
In a previous work, it was shown that the main effect of the A26G mutation was the activation of the intrinsic GTPase of SsEF-2 [De Vendittis, E., Adinolfi, B. S., Amatruda, M. R., Raimo, G., Masullo, M., and Bocchini, V. (1994) Eur. J. ...In this work, we fo …
In a previous work, it was shown that the main effect of the A26G mutation was the activation of the intrinsic GTPase of SsEF-2 [De Venditti …