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Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.
Teno N, Yamashita Y, Masuda A, Iguchi Y, Oda K, Fujimori K, Hiramoto T, Nishimaki-Mogami T, Une M, Gohda K. Teno N, et al. Among authors: masuda a. Bioorg Med Chem. 2019 Jun 1;27(11):2220-2227. doi: 10.1016/j.bmc.2019.04.029. Epub 2019 Apr 20. Bioorg Med Chem. 2019. PMID: 31029550
Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity relationship analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism.
Gohda K, Iguchi Y, Masuda A, Fujimori K, Yamashita Y, Teno N. Gohda K, et al. Among authors: masuda a. Bioorg Med Chem Lett. 2021 Jun 1;41:128026. doi: 10.1016/j.bmcl.2021.128026. Epub 2021 Apr 9. Bioorg Med Chem Lett. 2021. PMID: 33839252
Discovery of FXR/PPARγ dual partial agonist.
Yamashita Y, Gohda K, Iguchi Y, Fujimori K, Oda K, Masuda A, Une M, Teno N. Yamashita Y, et al. Among authors: masuda a. Bioorg Med Chem. 2023 May 1;85:117238. doi: 10.1016/j.bmc.2023.117238. Epub 2023 Mar 24. Bioorg Med Chem. 2023. PMID: 37028120
Temporal progression of pancreatic cancer computed tomography findings until diagnosis: A large-scale multicenter study.
Gonda M, Masuda A, Kobayashi T, Iemoto T, Kakuyama S, Ezaki T, Ikegawa T, Hirata Y, Tsumura H, Ogisu K, Nakano R, Fujigaki S, Nakagawa T, Takagi M, Yamanaka K, Sato Y, Fujita K, Furumatsu K, Kato T, Sakai A, Shiomi H, Sanuki T, Arisaka Y, Okabe Y, Toyama H, Sofue K, Kodama Y. Gonda M, et al. Among authors: masuda a. United European Gastroenterol J. 2024 Mar 7. doi: 10.1002/ueg2.12557. Online ahead of print. United European Gastroenterol J. 2024. PMID: 38451583 Free article.
1,151 results