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Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals.
Bioorg Med Chem Lett. 2020 Jun 15;30(12):127186. doi: 10.1016/j.bmcl.2020.127186. Epub 2020 Apr 11.
Bioorg Med Chem Lett. 2020.
PMID: 32312583
Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.
Salla M, Butler MS, Massey NL, Reid JC, Cooper MA, Robertson AAB.
Salla M, et al. Among authors: massey nl.
Bioorg Med Chem Lett. 2018 Feb 15;28(4):793-795. doi: 10.1016/j.bmcl.2017.12.054. Epub 2017 Dec 26.
Bioorg Med Chem Lett. 2018.
PMID: 29338910
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K.
Coll RC, et al. Among authors: massey nl.
Nat Chem Biol. 2019 Jun;15(6):556-559. doi: 10.1038/s41589-019-0277-7. Epub 2019 May 13.
Nat Chem Biol. 2019.
PMID: 31086327
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Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function.
Li XX, Lee JD, Massey NL, Guan C, Robertson AAB, Clark RJ, Woodruff TM.
Li XX, et al. Among authors: massey nl.
Biochem Pharmacol. 2020 Oct;180:114156. doi: 10.1016/j.bcp.2020.114156. Epub 2020 Jul 17.
Biochem Pharmacol. 2020.
PMID: 32682759
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Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.
Schofield ZV, Croker D, Robertson AAB, Massey NL, Donovan C, Tee E, Edwards D, Woodruff TM, Halai R, Hansbro PM, Cooper MA.
Schofield ZV, et al. Among authors: massey nl.
Sci Rep. 2018 Dec 13;8(1):17819. doi: 10.1038/s41598-018-36242-1.
Sci Rep. 2018.
PMID: 30546040
Free PMC article.
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