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Structural basis for chain release from the enacyloxin polyketide synthase.
Kosol S, Gallo A, Griffiths D, Valentic TR, Masschelein J, Jenner M, de Los Santos ELC, Manzi L, Sydor PK, Rea D, Zhou S, Fülöp V, Oldham NJ, Tsai SC, Challis GL, Lewandowski JR. Kosol S, et al. Among authors: masschelein j. Nat Chem. 2019 Oct;11(10):913-923. doi: 10.1038/s41557-019-0335-5. Epub 2019 Sep 23. Nat Chem. 2019. PMID: 31548674 Free PMC article.
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis.
Song L, Jenner M, Masschelein J, Jones C, Bull MJ, Harris SR, Hartkoorn RC, Vocat A, Romero-Canelon I, Coupland P, Webster G, Dunn M, Weiser R, Paisey C, Cole ST, Parkhill J, Mahenthiralingam E, Challis GL. Song L, et al. Among authors: masschelein j. J Am Chem Soc. 2017 Jun 14;139(23):7974-7981. doi: 10.1021/jacs.7b03382. Epub 2017 Jun 5. J Am Chem Soc. 2017. PMID: 28528545 Free article.
An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibiotics.
Jenner M, Jian X, Dashti Y, Masschelein J, Hobson C, Roberts DM, Jones C, Harris S, Parkhill J, Raja HA, Oberlies NH, Pearce CJ, Mahenthiralingam E, Challis GL. Jenner M, et al. Among authors: masschelein j. Chem Sci. 2019 Apr 25;10(21):5489-5494. doi: 10.1039/c8sc04897e. eCollection 2019 Jun 7. Chem Sci. 2019. PMID: 31293732 Free PMC article.
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI.
Fage CD, Lathouwers T, Vanmeert M, Gao LJ, Vrancken K, Lammens EM, Weir ANM, Degroote R, Cuppens H, Kosol S, Simpson TJ, Crump MP, Willis CL, Herdewijn P, Lescrinier E, Lavigne R, Anné J, Masschelein J. Fage CD, et al. Among authors: masschelein j. Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10549-10556. doi: 10.1002/anie.201915407. Epub 2020 Apr 14. Angew Chem Int Ed Engl. 2020. PMID: 32208550
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.
Nakou IT, Jenner M, Dashti Y, Romero-Canelón I, Masschelein J, Mahenthiralingam E, Challis GL. Nakou IT, et al. Among authors: masschelein j. Angew Chem Int Ed Engl. 2020 Dec 14;59(51):23145-23153. doi: 10.1002/anie.202009007. Epub 2020 Oct 26. Angew Chem Int Ed Engl. 2020. PMID: 32918852 Free PMC article.
26 results