Massarotti A - Search Results

1

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC. Galli U, et al. Among authors: massarotti a. J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27. J Med Chem. 2015. PMID: 25584687

2

Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents.

Pirali T, Busacca S, Beltrami L, Imovilli D, Pagliai F, Miglio G, Massarotti A, Verotta L, Tron GC, Sorba G, Genazzani AA. Pirali T, et al. Among authors: massarotti a. J Med Chem. 2006 Aug 24;49(17):5372-6. doi: 10.1021/jm060621o. J Med Chem. 2006. PMID: 16913727

3

Solution-phase parallel synthesis and biological evaluation of combretatriazoles.

Cafici L, Pirali T, Condorelli F, Del Grosso E, Massarotti A, Sorba G, Canonico PL, Tron GC, Genazzani AA. Cafici L, et al. Among authors: massarotti a. J Comb Chem. 2008 Sep-Oct;10(5):732-40. doi: 10.1021/cc800090d. Epub 2008 Aug 6. J Comb Chem. 2008. PMID: 18681482

4

Replacement of the double bond of antitubulin chalcones with triazoles and tetrazoles: Synthesis and biological evaluation.

Mesenzani O, Massarotti A, Giustiniano M, Pirali T, Bevilacqua V, Caldarelli A, Canonico P, Sorba G, Novellino E, Genazzani AA, Tron GC. Mesenzani O, et al. Among authors: massarotti a. Bioorg Med Chem Lett. 2011 Jan 15;21(2):764-8. doi: 10.1016/j.bmcl.2010.11.113. Epub 2010 Nov 28. Bioorg Med Chem Lett. 2011. PMID: 21167709

5

Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.

Theeramunkong S, Caldarelli A, Massarotti A, Aprile S, Caprioglio D, Zaninetti R, Teruggi A, Pirali T, Grosa G, Tron GC, Genazzani AA. Theeramunkong S, et al. Among authors: massarotti a. J Med Chem. 2011 Jul 28;54(14):4977-86. doi: 10.1021/jm200555r. Epub 2011 Jun 30. J Med Chem. 2011. PMID: 21696175

6

Identification of novel antitubulin agents by using a virtual screening approach based on a 7-point pharmacophore model of the tubulin colchi-site.

Massarotti A, Theeramunkong S, Mesenzani O, Caldarelli A, Genazzani AA, Tron GC. Massarotti A, et al. Chem Biol Drug Des. 2011 Dec;78(6):913-22. doi: 10.1111/j.1747-0285.2011.01245.x. Epub 2011 Oct 31. Chem Biol Drug Des. 2011. PMID: 22039890

7

A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents.

Zaninetti R, Cortese SV, Aprile S, Massarotti A, Canonico PL, Sorba G, Grosa G, Genazzani AA, Pirali T. Zaninetti R, et al. Among authors: massarotti a. ChemMedChem. 2013 Apr;8(4):633-43. doi: 10.1002/cmdc.201200561. Epub 2013 Feb 21. ChemMedChem. 2013. PMID: 23436706

8

Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.

Galli U, Travelli C, Massarotti A, Fakhfouri G, Rahimian R, Tron GC, Genazzani AA. Galli U, et al. Among authors: massarotti a. J Med Chem. 2013 Aug 22;56(16):6279-96. doi: 10.1021/jm4001049. Epub 2013 May 31. J Med Chem. 2013. PMID: 23679915 Review.

9

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC. Travelli C, et al. Among authors: massarotti a. J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22. J Med Chem. 2017. PMID: 28165742

10

Discovery of Highly Potent Benzimidazole Derivatives as Indoleamine 2,3-Dioxygenase-1 (IDO1) Inhibitors: From Structure-Based Virtual Screening to in Vivo Pharmacodynamic Activity.

Serafini M, Torre E, Aprile S, Grosso ED, Gesù A, Griglio A, Colombo G, Travelli C, Paiella S, Adamo A, Orecchini E, Coletti A, Pallotta MT, Ugel S, Massarotti A, Pirali T, Fallarini S. Serafini M, et al. Among authors: massarotti a. J Med Chem. 2020 Mar 26;63(6):3047-3065. doi: 10.1021/acs.jmedchem.9b01809. Epub 2020 Mar 17. J Med Chem. 2020. PMID: 32150677

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