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Machine learning-powered antibiotics phenotypic drug discovery.
Zoffmann S, Vercruysse M, Benmansour F, Maunz A, Wolf L, Blum Marti R, Heckel T, Ding H, Truong HH, Prummer M, Schmucki R, Mason CS, Bradley K, Jacob AI, Lerner C, Araujo Del Rosario A, Burcin M, Amrein KE, Prunotto M. Zoffmann S, et al. Among authors: mason cs. Sci Rep. 2019 Mar 21;9(1):5013. doi: 10.1038/s41598-019-39387-9. Sci Rep. 2019. PMID: 30899034 Free PMC article.
Targeted microbiome-sparing antibiotics.
Avis T, Wilson FX, Khan N, Mason CS, Powell DJ. Avis T, et al. Among authors: mason cs. Drug Discov Today. 2021 Sep;26(9):2198-2203. doi: 10.1016/j.drudis.2021.07.016. Epub 2021 Jul 28. Drug Discov Today. 2021. PMID: 34329771 Free article. Review.
High-density transposon libraries utilising outward-oriented promoters identify mechanisms of action and resistance to antimicrobials.
Coward C, Dharmalingham G, Abdulle O, Avis T, Beisken S, Breidenstein E, Carli N, Figueiredo L, Jones D, Khan N, Malara S, Martins J, Nagalingam N, Turner K, Wain J, Williams D, Powell D, Mason C. Coward C, et al. FEMS Microbiol Lett. 2020 Dec 14;367(22):fnaa185. doi: 10.1093/femsle/fnaa185. FEMS Microbiol Lett. 2020. PMID: 33186989 Free PMC article.
A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections.
Blaskovich MAT, Hansford KA, Butler MS, Ramu S, Kavanagh AM, Jarrad AM, Prasetyoputri A, Pitt ME, Huang JX, Lindahl F, Ziora ZM, Bradford T, Muldoon C, Rajaratnam P, Pelingon R, Edwards DJ, Zhang B, Amado M, Elliott AG, Zuegg J, Coin L, Woischnig AK, Khanna N, Breidenstein E, Stincone A, Mason C, Khan N, Cho HK, Karau MJ, Greenwood-Quaintance KE, Patel R, Wootton M, James ML, Hutton ML, Lyras D, Ogunniyi AD, Mahdi LK, Trott DJ, Wu X, Niles S, Lewis K, Smith JR, Barber KE, Yim J, Rice SA, Rybak MJ, Ishmael CR, Hori KR, Bernthal NM, Francis KP, Roberts JA, Paterson DL, Cooper MA. Blaskovich MAT, et al. Sci Transl Med. 2022 Sep 14;14(662):eabj2381. doi: 10.1126/scitranslmed.abj2381. Epub 2022 Sep 14. Sci Transl Med. 2022. PMID: 36103517
37 results