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Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology.
Navarro-Romero A, Fernandez-Gonzalez I, Riera J, Montpeyo M, Albert-Bayo M, Lopez-Royo T, Castillo-Sanchez P, Carnicer-Caceres C, Arranz-Amo JA, Castillo-Ribelles L, Pradas E, Casas J, Vila M, Martinez-Vicente M. Navarro-Romero A, et al. Among authors: martinez vicente m. NPJ Parkinsons Dis. 2022 Oct 6;8(1):126. doi: 10.1038/s41531-022-00397-6. NPJ Parkinsons Dis. 2022. PMID: 36202848 Free PMC article.
Lysosomal impairment in Parkinson's disease.
Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E. Dehay B, et al. Mov Disord. 2013 Jun;28(6):725-32. doi: 10.1002/mds.25462. Epub 2013 Apr 11. Mov Disord. 2013. PMID: 23580333 Free PMC article. Review.
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Carballo-Carbajal I, Laguna A, Romero-Giménez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodríguez-Galván B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M. Carballo-Carbajal I, et al. Nat Commun. 2019 Mar 7;10(1):973. doi: 10.1038/s41467-019-08858-y. Nat Commun. 2019. PMID: 30846695 Free PMC article.
54 results