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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62.
Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo HH, Elemento O, Martin ML, Cordes T, Thompson TC, Metallo CM, Moscat J, Diaz-Meco MT. Linares JF, et al. Among authors: martinez ordonez a. Cell Rep. 2022 May 10;39(6):110792. doi: 10.1016/j.celrep.2022.110792. Cell Rep. 2022. PMID: 35545049 Free PMC article.
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L'Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT, Moscat J. Kasashima H, et al. Among authors: martinez ordonez a. Dev Cell. 2021 Jan 11;56(1):95-110.e10. doi: 10.1016/j.devcel.2020.10.014. Epub 2020 Nov 17. Dev Cell. 2021. PMID: 33207226 Free PMC article.
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J. Linares JF, et al. Among authors: martinez ordonez a. Mol Cell. 2021 Nov 4;81(21):4509-4526.e10. doi: 10.1016/j.molcel.2021.08.039. Epub 2021 Sep 23. Mol Cell. 2021. PMID: 34560002 Free PMC article.
16 results