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Page 1
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5822-6. doi: 10.1016/j.bmcl.2006.08.066. Epub 2006 Aug 30. Bioorg Med Chem Lett. 2006. PMID: 16942871
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Reiter LA, Mitchell PG, Martinelli GJ, Lopresti-Morrow LL, Yocum SA, Eskra JD. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2331-6. doi: 10.1016/s0960-894x(03)00413-x. Bioorg Med Chem Lett. 2003. PMID: 12824028
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Reiter LA, Robinson RP, McClure KF, Jones CS, Reese MR, Mitchell PG, Otterness IG, Bliven ML, Liras J, Cortina SR, Donahue KM, Eskra JD, Griffiths RJ, Lame ME, Lopez-Anaya A, Martinelli GJ, McGahee SM, Yocum SA, Lopresti-Morrow LL, Tobiassen LM, Vaughn-Bowser ML. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3389-95. doi: 10.1016/j.bmcl.2004.04.083. Bioorg Med Chem Lett. 2004. PMID: 15177439
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA. Freeman-Cook KD, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. doi: 10.1016/j.bmcl.2007.09.085. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17935984
Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.
Reiter LA, Rizzi JP, Pandit J, Lasut MJ, McGahee SM, Parikh VD, Blake JF, Danley DE, Laird ER, Lopez-Anaya A, Lopresti-Morrow LL, Mansour MN, Martinelli GJ, Mitchell PG, Owens BS, Pauly TA, Reeves LM, Schulte GK, Yocum SA. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 1999 Jan 18;9(2):127-32. doi: 10.1016/s0960-894x(98)00729-x. Bioorg Med Chem Lett. 1999. PMID: 10021913
Difluoroketones as inhibitors of matrix metalloprotease-13.
Reiter LA, Martinelli GJ, Reeves LA, Mitchell PG. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1581-4. doi: 10.1016/s0960-894x(00)00287-0. Bioorg Med Chem Lett. 2000. PMID: 10915056
Design of selective, ATP-competitive inhibitors of Akt.
Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J. Freeman-Cook KD, et al. J Med Chem. 2010 Jun 24;53(12):4615-22. doi: 10.1021/jm1003842. J Med Chem. 2010. PMID: 20481595
Synthesis and biological evaluation of novel hygromycin A antibacterial agents.
Visser MS, Freeman-Cook KD, Brickner SJ, Brighty KE, Le PT, Wade SK, Monahan R, Martinelli GJ, Blair KT, Moore DE. Visser MS, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6730-4. doi: 10.1016/j.bmcl.2010.08.139. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20864341
trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.
Reiter LA, Koch K, Piscopio AD, Showell HJ, Alpert R, Biggers MS, Chambers RJ, Conklyn MJ, Cooper K, Cortina SR, Dibrino JN, Dominy BW, Farrell CA, Hingorani GP, Martinelli GJ, Ramchandani M, Wright KF. Reiter LA, et al. Among authors: martinelli gj. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1781-6. doi: 10.1016/s0960-894x(98)00275-3. Bioorg Med Chem Lett. 1998. PMID: 9873433