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TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Maifrede S, Le BV, Nieborowska-Skorska M, Golovine K, Sullivan-Reed K, Dunuwille WMB, Nacson J, Hulse M, Keith K, Madzo J, Caruso LB, Gazze Z, Lian Z, Padella A, Chitrala KN, Bartholdy BA, Matlawska-Wasowska K, Di Marcantonio D, Simonetti G, Greiner G, Sykes SM, Valent P, Paietta EM, Tallman MS, Fernandez HF, Litzow MR, Minden MD, Huang J, Martinelli G, Vassiliou GS, Tempera I, Piwocka K, Johnson N, Challen GA, Skorski T. Maifrede S, et al. Among authors: martinelli g. Cancer Res. 2021 Oct 1;81(19):5089-5101. doi: 10.1158/0008-5472.CAN-20-3761. Epub 2021 Jul 2. Cancer Res. 2021. PMID: 34215619 Free PMC article.
Protein tyrosine phosphatase receptor type {gamma} is a functional tumor suppressor gene specifically downregulated in chronic myeloid leukemia.
Della Peruta M, Martinelli G, Moratti E, Pintani D, Vezzalini M, Mafficini A, Grafone T, Iacobucci I, Soverini S, Murineddu M, Vinante F, Tecchio C, Piras G, Gabbas A, Monne M, Sorio C. Della Peruta M, et al. Among authors: martinelli g. Cancer Res. 2010 Nov 1;70(21):8896-906. doi: 10.1158/0008-5472.CAN-10-0258. Epub 2010 Oct 19. Cancer Res. 2010. PMID: 20959494
c-MYC oncoprotein dictates transcriptional profiles of ATP-binding cassette transporter genes in chronic myelogenous leukemia CD34+ hematopoietic progenitor cells.
Porro A, Iraci N, Soverini S, Diolaiti D, Gherardi S, Terragna C, Durante S, Valli E, Kalebic T, Bernardoni R, Perrod C, Haber M, Norris MD, Baccarani M, Martinelli G, Perini G. Porro A, et al. Among authors: martinelli g. Mol Cancer Res. 2011 Aug;9(8):1054-66. doi: 10.1158/1541-7786.MCR-10-0510. Epub 2011 Jun 21. Mol Cancer Res. 2011. PMID: 21693596
Drug resistance and BCR-ABL kinase domain mutations in Philadelphia chromosome-positive acute lymphoblastic leukemia from the imatinib to the second-generation tyrosine kinase inhibitor era: The main changes are in the type of mutations, but not in the frequency of mutation involvement.
Soverini S, De Benedittis C, Papayannidis C, Paolini S, Venturi C, Iacobucci I, Luppi M, Bresciani P, Salvucci M, Russo D, Sica S, Orlandi E, Intermesoli T, Gozzini A, Bonifacio M, Rigolin GM, Pane F, Baccarani M, Cavo M, Martinelli G. Soverini S, et al. Among authors: martinelli g. Cancer. 2014 Apr 1;120(7):1002-9. doi: 10.1002/cncr.28522. Epub 2013 Dec 30. Cancer. 2014. PMID: 24382642 Free article.
Fanconi anemia gene variants in therapy-related myeloid neoplasms.
Voso MT, Fabiani E, Zang Z, Fianchi L, Falconi G, Padella A, Martini M, Li Zhang S, Santangelo R, Larocca LM, Criscuolo M, La Brocca A, Cutcutache I, Rozen S, Simonetti G, Manfrini M, Martinelli G, Hohaus S, Leone G, Tan P, Tenen DG. Voso MT, et al. Among authors: martinelli g. Blood Cancer J. 2015 Jul 3;5(7):e323. doi: 10.1038/bcj.2015.44. Blood Cancer J. 2015. PMID: 26140431 Free PMC article. No abstract available.
Aneuploidy: Cancer strength or vulnerability?
Simonetti G, Bruno S, Padella A, Tenti E, Martinelli G. Simonetti G, et al. Among authors: martinelli g. Int J Cancer. 2019 Jan 1;144(1):8-25. doi: 10.1002/ijc.31718. Epub 2018 Oct 31. Int J Cancer. 2019. PMID: 29981145 Free PMC article. Review.
Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery.
Simonetti G, Padella A, do Valle IF, Fontana MC, Fonzi E, Bruno S, Baldazzi C, Guadagnuolo V, Manfrini M, Ferrari A, Paolini S, Papayannidis C, Marconi G, Franchini E, Zuffa E, Laginestra MA, Zanotti F, Astolfi A, Iacobucci I, Bernardi S, Sazzini M, Ficarra E, Hernandez JM, Vandenberghe P, Cools J, Bullinger L, Ottaviani E, Testoni N, Cavo M, Haferlach T, Castellani G, Remondini D, Martinelli G. Simonetti G, et al. Among authors: martinelli g. Cancer. 2019 Mar 1;125(5):712-725. doi: 10.1002/cncr.31837. Epub 2018 Nov 27. Cancer. 2019. PMID: 30480765 Free PMC article.
Chronic myeloid leukemia stem cells.
Houshmand M, Simonetti G, Circosta P, Gaidano V, Cignetti A, Martinelli G, Saglio G, Gale RP. Houshmand M, et al. Among authors: martinelli g. Leukemia. 2019 Jul;33(7):1543-1556. doi: 10.1038/s41375-019-0490-0. Epub 2019 May 24. Leukemia. 2019. PMID: 31127148 Free PMC article. Review.
Synergism Through WEE1 and CHK1 Inhibition in Acute Lymphoblastic Leukemia.
Ghelli Luserna Di Rorà A, Bocconcelli M, Ferrari A, Terragna C, Bruno S, Imbrogno E, Beeharry N, Robustelli V, Ghetti M, Napolitano R, Chirumbolo G, Marconi G, Papayannidis C, Paolini S, Sartor C, Simonetti G, Yen TJ, Martinelli G. Ghelli Luserna Di Rorà A, et al. Among authors: martinelli g. Cancers (Basel). 2019 Oct 25;11(11):1654. doi: 10.3390/cancers11111654. Cancers (Basel). 2019. PMID: 31717700 Free PMC article.
1,445 results