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Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Feng S, Yang M, Zhang Z, Wang Z, Hong D, Richter H, Benson GM, Bleicher K, Grether U, Martin RE, Plancher JM, Kuhn B, Rudolph MG, Chen L. Feng S, et al. Among authors: martin re. Bioorg Med Chem Lett. 2009 May 1;19(9):2595-8. doi: 10.1016/j.bmcl.2009.03.008. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19328688
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties.
Richter HG, Benson GM, Bleicher KH, Blum D, Chaput E, Clemann N, Feng S, Gardes C, Grether U, Hartman P, Kuhn B, Martin RE, Plancher JM, Rudolph MG, Schuler F, Taylor S. Richter HG, et al. Among authors: martin re. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1134-40. doi: 10.1016/j.bmcl.2010.12.123. Epub 2010 Dec 31. Bioorg Med Chem Lett. 2011. PMID: 21269824
G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.
Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L. Kratochwil NA, et al. Among authors: martin re. Curr Top Med Chem. 2011;11(15):1902-24. doi: 10.2174/156802611796391267. Curr Top Med Chem. 2011. PMID: 21470172
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.
Dehmlow H, Alvarez Sánchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Dehmlow H, et al. Among authors: martin re. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. Bioorg Med Chem Lett. 2013. PMID: 23831134
367 results