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Page 1
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Among authors: martin ni. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Review.
Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics.
Gao Y, van Haren MJ, Buijs N, Innocenti P, Zhang Y, Sartini D, Campagna R, Emanuelli M, Parsons RB, Jespers W, Gutiérrez-de-Terán H, van Westen GJP, Martin NI. Gao Y, et al. Among authors: martin ni. J Med Chem. 2021 Sep 9;64(17):12938-12963. doi: 10.1021/acs.jmedchem.1c01094. Epub 2021 Aug 23. J Med Chem. 2021. PMID: 34424711 Free PMC article.
Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.
Bakker AT, Kotsogianni I, Mirenda L, Straub VM, Avalos M, van den Berg RJBHN, Florea BI, van Wezel GP, Janssen APA, Martin NI, van der Stelt M. Bakker AT, et al. Among authors: martin ni. J Am Chem Soc. 2023 Jan 18;145(2):1136-1143. doi: 10.1021/jacs.2c10819. Epub 2022 Dec 30. J Am Chem Soc. 2023. PMID: 36584241 Free PMC article.
Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability.
Al Ayed K, Zamarbide Losada D, Machushynets NV, Terlouw B, Elsayed SS, Schill J, Trebosc V, Pieren M, Medema MH, van Wezel GP, Martin NI. Al Ayed K, et al. Among authors: martin ni. ACS Infect Dis. 2023 Apr 14;9(4):739-748. doi: 10.1021/acsinfecdis.3c00043. Epub 2023 Mar 31. ACS Infect Dis. 2023. PMID: 37000899 Free PMC article.
Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.
Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: martin ni. ACS Chem Biol. 2024 Apr 11. doi: 10.1021/acschembio.4c00034. Online ahead of print. ACS Chem Biol. 2024. PMID: 38602492
Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.
Wood TM, Zeronian MR, Buijs N, Bertheussen K, Abedian HK, Johnson AV, Pearce NM, Lutz M, Kemmink J, Seirsma T, Hamoen LW, Janssen BJC, Martin NI. Wood TM, et al. Among authors: martin ni. Chem Sci. 2022 Feb 21;13(10):2985-2991. doi: 10.1039/d1sc07190d. eCollection 2022 Mar 9. Chem Sci. 2022. PMID: 35382464 Free PMC article.
122 results