Martin MD - Search Results

1

Spermidine/spermine-N¹-acetyltransferase ablation impacts tauopathy-induced polyamine stress response.

Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, Selenica MB, Nash KR, Gordon MN, Morgan D, Lee DC. Sandusky-Beltran LA, et al. Among authors: martin md. Alzheimers Res Ther. 2019 Jun 29;11(1):58. doi: 10.1186/s13195-019-0507-y. Alzheimers Res Ther. 2019. PMID: 31253191 Free PMC article.

2

Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.

Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Martin MD, et al. ACS Chem Biol. 2015 Apr 17;10(4):1099-109. doi: 10.1021/cb501013w. Epub 2015 Jan 30. ACS Chem Biol. 2015. PMID: 25588114 Free PMC article.

3

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

Fontaine SN, Martin MD, Akoury E, Assimon VA, Borysov S, Nordhues BA, Sabbagh JJ, Cockman M, Gestwicki JE, Zweckstetter M, Dickey CA. Fontaine SN, et al. Among authors: martin md. Hum Mol Genet. 2015 Jul 15;24(14):3971-81. doi: 10.1093/hmg/ddv135. Epub 2015 Apr 16. Hum Mol Genet. 2015. PMID: 25882706 Free PMC article.

4

Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development.

Fontaine SN, Martin MD, Dickey CA. Fontaine SN, et al. Among authors: martin md. Curr Top Med Chem. 2016;16(25):2741-52. doi: 10.2174/1568026616666160413140741. Curr Top Med Chem. 2016. PMID: 27072702 Review.

5

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA. Martin MD, et al. ACS Chem Biol. 2016 Jul 15;11(7):2041-8. doi: 10.1021/acschembio.6b00223. Epub 2016 May 26. ACS Chem Biol. 2016. PMID: 27177119 Free PMC article.

6

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA. Fontaine SN, et al. Among authors: martin md. EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3. EMBO J. 2016. PMID: 27261198 Free PMC article.

7

Human cyclophilin 40 unravels neurotoxic amyloids.

Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ. Baker JD, et al. Among authors: martin md. PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun. PLoS Biol. 2017. PMID: 28654636 Free PMC article.

8

Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations.

Hill SE, Kwon MS, Martin MD, Suntharalingam A, Hazel A, Dickey CA, Gumbart JC, Lieberman RL. Hill SE, et al. Among authors: martin md. J Biol Chem. 2019 Aug 23;294(34):12717-12728. doi: 10.1074/jbc.RA119.009419. Epub 2019 Jul 2. J Biol Chem. 2019. PMID: 31270212 Free PMC article.

9

Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.

Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Ospina SR, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, Blair LJ. Hill SE, et al. Among authors: martin md. ACS Chem Biol. 2023 May 19;18(5):1124-1135. doi: 10.1021/acschembio.2c00919. Epub 2023 May 5. ACS Chem Biol. 2023. PMID: 37144894

10

Ancient reindeer mitogenomes reveal island-hopping colonisation of the Arctic archipelagos.

Hold K, Lord E, Brealey JC, Le Moullec M, Bieker VC, Ellegaard MR, Rasmussen JA, Kellner FL, Guschanski K, Yannic G, Røed KH, Hansen BB, Dalén L, Martin MD, Dussex N. Hold K, et al. Among authors: martin md. Sci Rep. 2024 Feb 20;14(1):4143. doi: 10.1038/s41598-024-54296-2. Sci Rep. 2024. PMID: 38374421 Free PMC article.

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