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Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.
Wegner MS, Schömel N, Olzomer EM, Trautmann S, Olesch C, Byrne FL, Brüne B, Gurke R, Ferreirós N, Weigert A, Geisslinger G, Hoehn KL. Wegner MS, et al. Cell Mol Life Sci. 2021 Nov;78(21-22):7025-7041. doi: 10.1007/s00018-021-03958-9. Epub 2021 Oct 9. Cell Mol Life Sci. 2021. PMID: 34626204 Free PMC article.
UGCG influences glutamine metabolism of breast cancer cells.
Schömel N, Hancock SE, Gruber L, Olzomer EM, Byrne FL, Shah D, Hoehn KL, Turner N, Grösch S, Geisslinger G, Wegner MS. Schömel N, et al. Among authors: wegner ms. Sci Rep. 2019 Oct 30;9(1):15665. doi: 10.1038/s41598-019-52169-7. Sci Rep. 2019. PMID: 31666638 Free PMC article.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S. Brachtendorf S, et al. Among authors: wegner ms. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1214-1227. doi: 10.1016/j.bbalip.2018.07.011. Epub 2018 Jul 27. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 30059758
18 results