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ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome.
Rodríguez-Ruiz L, Lozano-Gil JM, Naranjo-Sánchez E, Martínez-Balsalobre E, Martínez-López A, Lachaud C, Blanquer M, Phung TK, García-Moreno D, Cayuela ML, Tyrkalska SD, Pérez-Oliva AB, Mulero V. Rodríguez-Ruiz L, et al. Among authors: martinez balsalobre e. EMBO Mol Med. 2023 Oct 11;15(10):e18142. doi: 10.15252/emmm.202318142. Epub 2023 Sep 7. EMBO Mol Med. 2023. PMID: 37675820 Free PMC article.
Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness.
Bernabé-García M, Martínez-Balsalobre E, García-Moreno D, García-Castillo J, Revilla-Nuin B, Blanco-Alcaina E, Mulero V, Alcaraz-Pérez F, Cayuela ML. Bernabé-García M, et al. Among authors: martinez balsalobre e. Mol Oncol. 2021 Jul;15(7):1818-1834. doi: 10.1002/1878-0261.12943. Epub 2021 May 2. Mol Oncol. 2021. PMID: 33713376 Free PMC article.
Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.
García-Castillo J, Alcaraz-Pérez F, Martínez-Balsalobre E, García-Moreno D, Rossmann MP, Fernández-Lajarín M, Bernabé-García M, Pérez-Oliva AB, Rodríguez-Cortez VC, Bueno C, Adatto I, Agarwal S, Menéndez P, Zon LI, Mulero V, Cayuela ML. García-Castillo J, et al. Among authors: martinez balsalobre e. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2015528118. doi: 10.1073/pnas.2015528118. Proc Natl Acad Sci U S A. 2021. PMID: 34353901 Free PMC article.
UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival.
Lee L, Perez Oliva AB, Martinez-Balsalobre E, Churikov D, Peter J, Rahmouni D, Audoly G, Azzoni V, Audebert S, Camoin L, Mulero V, Cayuela ML, Kulathu Y, Geli V, Lachaud C. Lee L, et al. Among authors: martinez balsalobre e. Sci Adv. 2021 Sep 24;7(39):eabc7371. doi: 10.1126/sciadv.abc7371. Epub 2021 Sep 24. Sci Adv. 2021. PMID: 34559557 Free PMC article.
Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation.
Peris I, Romero-Murillo S, Martínez-Balsalobre E, Farrington CC, Arriazu E, Marcotegui N, Jiménez-Muñoz M, Alburquerque-Prieto C, Torres-López A, Fresquet V, Martínez-Climent JA, Mateos MC, Cayuela ML, Narla G, Odero MD, Vicente C. Peris I, et al. Among authors: martinez balsalobre e. Blood. 2023 Mar 2;141(9):1047-1059. doi: 10.1182/blood.2022016466. Blood. 2023. PMID: 36455198 Free PMC article.
A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity.
Vicente C, Arriazu E, Martínez-Balsalobre E, Peris I, Marcotegui N, García-Ramírez P, Pippa R, Rabal O, Oyarzábal J, Guruceaga E, Prósper F, Mateos MC, Cayuela ML, Odero MD. Vicente C, et al. Among authors: martinez balsalobre e. Cancer Lett. 2020 Jan 1;468:1-13. doi: 10.1016/j.canlet.2019.10.007. Epub 2019 Oct 5. Cancer Lett. 2020. PMID: 31593801
A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia.
Arriazu E, Vicente C, Pippa R, Peris I, Martínez-Balsalobre E, García-Ramírez P, Marcotegui N, Igea A, Alignani D, Rifón J, Mateos MC, Cayuela ML, Nebreda AR, Odero MD. Arriazu E, et al. Among authors: martinez balsalobre e. Blood Cancer J. 2020 Jan 8;10(1):3. doi: 10.1038/s41408-019-0270-0. Blood Cancer J. 2020. PMID: 31913266 Free PMC article.
A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells.
Berrada S, Martínez-Balsalobre E, Larcher L, Azzoni V, Vasquez N, Da Costa M, Abel S, Audoly G, Lee L, Montersino C, Castellano R, Combes S, Gelot C, Ceccaldi R, Guervilly JH, Soulier J, Lachaud C. Berrada S, et al. Among authors: martinez balsalobre e. Nucleic Acids Res. 2023 Aug 25;51(15):7988-8004. doi: 10.1093/nar/gkad559. Nucleic Acids Res. 2023. PMID: 37395445 Free PMC article.