Martínez-Bailén M - Search Results

1

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars.

Pingitore V, Martínez-Bailén M, Carmona AT, Mészáros Z, Kulik N, Slámová K, Křen V, Bojarová P, Robina I, Moreno-Vargas AJ. Pingitore V, et al. Among authors: martinez bailen m. Bioorg Chem. 2022 Mar;120:105650. doi: 10.1016/j.bioorg.2022.105650. Epub 2022 Feb 2. Bioorg Chem. 2022. PMID: 35144103 Free article.

2

Tuning of β-glucosidase and α-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules.

Martínez-Bailén M, Carmona AT, Moreno-Clavijo E, Robina I, Ide D, Kato A, Moreno-Vargas AJ. Martínez-Bailén M, et al. Eur J Med Chem. 2017 Sep 29;138:532-542. doi: 10.1016/j.ejmech.2017.06.055. Epub 2017 Jun 27. Eur J Med Chem. 2017. PMID: 28692917

3

Exploring substituent diversity on pyrrolidine-aryltriazole iminosugars: Structural basis of β-glucocerebrosidase inhibition.

Martínez-Bailén M, Carmona AT, Patterson-Orazem AC, Lieberman RL, Ide D, Kubo M, Kato A, Robina I, Moreno-Vargas AJ. Martínez-Bailén M, et al. Bioorg Chem. 2019 May;86:652-664. doi: 10.1016/j.bioorg.2019.02.025. Epub 2019 Feb 12. Bioorg Chem. 2019. PMID: 30825709

4

Structural basis of the inhibition of GH1 β-glucosidases by multivalent pyrrolidine iminosugars.

Martínez-Bailén M, Jiménez-Ortega E, Carmona AT, Robina I, Sanz-Aparicio J, Talens-Perales D, Polaina J, Matassini C, Cardona F, Moreno-Vargas AJ. Martínez-Bailén M, et al. Bioorg Chem. 2019 Aug;89:103026. doi: 10.1016/j.bioorg.2019.103026. Epub 2019 Jun 4. Bioorg Chem. 2019. PMID: 31226649

5

Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease.

Martínez-Bailén M, Carmona AT, Cardona F, Matassini C, Goti A, Kubo M, Kato A, Robina I, Moreno-Vargas AJ. Martínez-Bailén M, et al. Eur J Med Chem. 2020 Apr 15;192:112173. doi: 10.1016/j.ejmech.2020.112173. Epub 2020 Feb 20. Eur J Med Chem. 2020. PMID: 32146376

6

Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer's disease.

Velueta-Viveros M, Martínez-Bailén M, Puerta A, Romero-Hernández LL, Křen V, Merino-Montiel P, Montiel-Smith S, Fernandes MX, Moreno-Vargas AJ, Padrón JM, López Ó, Fernández-Bolaños JG. Velueta-Viveros M, et al. Among authors: martinez bailen m. Bioorg Chem. 2022 Oct;127:105983. doi: 10.1016/j.bioorg.2022.105983. Epub 2022 Jun 25. Bioorg Chem. 2022. PMID: 35779403

7

Regioselectivity of the 1,3-Dipolar Cycloaddition of Organic Azides to 7-Heteronorbornadienes. Synthesis of β-Substituted Furans/Pyrroles.

Gil de Montes E, Martı Nez-Bailén M, Carmona AT, Robina I, Moreno-Vargas AJ. Gil de Montes E, et al. J Org Chem. 2020 Jul 17;85(14):8923-8932. doi: 10.1021/acs.joc.0c00810. Epub 2020 Jun 30. J Org Chem. 2020. PMID: 32519876

8

Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B.

Monaco S, Walpole S, Doukani H, Nepravishta R, Martínez-Bailén M, Carmona AT, Ramos-Soriano J, Bergström M, Robina I, Angulo J. Monaco S, et al. Among authors: martinez bailen m. Chemistry. 2020 Aug 6;26(44):10024-10034. doi: 10.1002/chem.202001723. Epub 2020 Jul 20. Chemistry. 2020. PMID: 32449563 Free PMC article.

9

Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning.

Clemente F, Matassini C, Faggi C, Giachetti S, Cresti C, Morrone A, Paoli P, Goti A, Martínez-Bailén M, Cardona F. Clemente F, et al. Bioorg Chem. 2020 May;98:103740. doi: 10.1016/j.bioorg.2020.103740. Epub 2020 Mar 9. Bioorg Chem. 2020. PMID: 32200326

10

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors.

Franco J, Piacente F, Walter M, Fratta S, Ghanem M, Benzi A, Caffa I, Kurkin AV, Altieri A, Herr P, Martínez-Bailén M, Robina I, Bruzzone S, Nencioni A, Del Rio A. Franco J, et al. Among authors: martinez bailen m. Pharmaceuticals (Basel). 2022 Jul 12;15(7):855. doi: 10.3390/ph15070855. Pharmaceuticals (Basel). 2022. PMID: 35890155 Free PMC article.

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