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EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.
Barroso R, Martínez Muñoz L, Barrondo S, Vega B, Holgado BL, Lucas P, Baíllo A, Sallés J, Rodríguez-Frade JM, Mellado M. Barroso R, et al. Among authors: martinez munoz l. FASEB J. 2012 Dec;26(12):4841-54. doi: 10.1096/fj.12-208876. Epub 2012 Aug 22. FASEB J. 2012. PMID: 22913878
CXCL12-mediated murine neural progenitor cell movement requires PI3Kβ activation.
Holgado BL, Martínez-Muñoz L, Sánchez-Alcañiz JA, Lucas P, Pérez-García V, Pérez G, Rodríguez-Frade JM, Nieto M, Marín O, Carrasco YR, Carrera AC, Alvarez-Dolado M, Mellado M. Holgado BL, et al. Among authors: martinez munoz l. Mol Neurobiol. 2013 Aug;48(1):217-31. doi: 10.1007/s12035-013-8451-5. Epub 2013 Apr 19. Mol Neurobiol. 2013. PMID: 23606281
CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.
Martínez-Muñoz L, Barroso R, Dyrhaug SY, Navarro G, Lucas P, Soriano SF, Vega B, Costas C, Muñoz-Fernández MÁ, Santiago C, Rodríguez Frade JM, Franco R, Mellado M. Martínez-Muñoz L, et al. Among authors: munoz fernandez ma. Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1960-9. doi: 10.1073/pnas.1322887111. Epub 2014 Apr 28. Proc Natl Acad Sci U S A. 2014. PMID: 24778234 Free PMC article.
Methods to immobilize GPCR on the surface of SPR sensors.
Martínez-Muñoz L, Barroso R, Paredes AG, Mellado M, Rodríguez-Frade JM. Martínez-Muñoz L, et al. Methods Mol Biol. 2015;1272:173-88. doi: 10.1007/978-1-4939-2336-6_12. Methods Mol Biol. 2015. PMID: 25563184
Chemokine Detection Using Receptors Immobilized on an SPR Sensor Surface.
Rodríguez-Frade JM, Martínez-Muñoz L, Villares R, Cascio G, Lucas P, Gomariz RP, Mellado M. Rodríguez-Frade JM, et al. Among authors: martinez munoz l. Methods Enzymol. 2016;570:1-18. doi: 10.1016/bs.mie.2015.09.013. Epub 2015 Nov 14. Methods Enzymol. 2016. PMID: 26921939 Review.
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.
Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B. Collins PJ, et al. Among authors: martinez munoz l. FASEB J. 2017 Jul;31(7):3084-3097. doi: 10.1096/fj.201700013R. Epub 2017 Mar 30. FASEB J. 2017. PMID: 28360196 Free PMC article.
Our findings provide new insights that will inform the development of novel therapeutics that target CXCR4 in a range of diseases, including cancer, autoimmunity, and HIV.-Collins, P. J., McCully, M. L., Martinez-Munoz, L., Santiago, C., Wheeldon, J., …
Our findings provide new insights that will inform the development of novel therapeutics that target CXCR4 in a range of diseases, including …
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.
Martínez-Muñoz L, Rodríguez-Frade JM, Barroso R, Sorzano CÓS, Torreño-Pina JA, Santiago CA, Manzo C, Lucas P, García-Cuesta EM, Gutierrez E, Barrio L, Vargas J, Cascio G, Carrasco YR, Sánchez-Madrid F, García-Parajo MF, Mellado M. Martínez-Muñoz L, et al. Mol Cell. 2018 Apr 5;70(1):106-119.e10. doi: 10.1016/j.molcel.2018.02.034. Mol Cell. 2018. PMID: 29625032 Free article.
32 results