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Page 1
Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Pérez PS, Robles JMR, Bermúdez-Jiménez FJ, Díaz-Agustín A, de Benito FM, Santiago SA, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: martin martinez m. bioRxiv [Preprint]. 2023 Jun 8:2023.06.07.544151. doi: 10.1101/2023.06.07.544151. bioRxiv. 2023. PMID: 37333254 Free PMC article. Preprint.
Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond.
Jennings SV, Finnerty CC, Hobart JS, Martín-Martínez M, Sinclair KA, Slee VM, Agopian J, Akin C, Álvarez-Twose I, Bonadonna P, Bowman AS, Brockow K, Bumbea H, de Haro C, Fok JS, Hartmann K, Hegmann N, Hermine O, Kalisiak M, Katelaris CH, Kurz J, Marcis P, Mayne D, Mendoza D, Moussy A, Mudretzkyj G, Vaia NN, Niedoszytko M, Elberink HO, Orfao A, Radia DH, Rosenmeier S, Ribada E, Schinhofen W, Schwaab J, Siebenhaar F, Triggiani M, Tripodo G, Velazquez R, Wielink Y, Wimazal F, Yigit T, Zubrinich C, Valent P. Jennings SV, et al. J Allergy Clin Immunol Pract. 2022 Aug;10(8):2039-2051. doi: 10.1016/j.jaip.2022.06.018. Epub 2022 Jun 28. J Allergy Clin Immunol Pract. 2022. PMID: 35777651 Free article.
An iterative structure-assisted approach to sequence alignment and comparative modeling.
Burke DF, Deane CM, Nagarajaram HA, Campillo N, Martin-Martinez M, Mendes J, Molina F, Perry J, Reddy BV, Soares CM, Steward RE, Williams M, Carrondo MA, Blundell TL, Mizuguchi K. Burke DF, et al. Proteins. 1999;Suppl 3:55-60. doi: 10.1002/(sici)1097-0134(1999)37:3+<55::aid-prot8>3.3.co;2-2. Proteins. 1999. PMID: 10526352
Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.
Gutiérrez-Rodríguez M, Martín-Martínez M, García-López MT, Herranz R, Cuevas F, Polanco C, Rodríguez-Campos I, Manzanares I, Cárdenas F, Feliz M, Lloyd-Williams P, Giralt E. Gutiérrez-Rodríguez M, et al. J Med Chem. 2004 Nov 4;47(23):5700-12. doi: 10.1021/jm040788m. J Med Chem. 2004. PMID: 15509169
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Alonso De Diego SA, Gutiérrez-Rodríguez M, Pérez de Vega MJ, González-Muñiz R, Herranz R, Martín-Martínez M, Cenarruzabeitia E, Frechilla D, Del Río J, Jimeno ML, García-López MT. Alonso De Diego SA, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. doi: 10.1016/j.bmcl.2006.04.033. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650992
Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents.
Peraza DA, Cercós P, Miaja P, Merinero YG, Lagartera L, Socuéllamos PG, Izquierdo García C, Sánchez SA, López-Hurtado A, Martín-Martínez M, Olivos-Oré LA, Naranjo JR, Artalejo AR, Gutiérrez-Rodríguez M, Valenzuela C. Peraza DA, et al. Front Mol Neurosci. 2019 Feb 4;12:11. doi: 10.3389/fnmol.2019.00011. eCollection 2019. Front Mol Neurosci. 2019. PMID: 30787866 Free PMC article.
Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs.
Cercós P, Peraza DA, Benito-Bueno A, Socuéllamos PG, Aziz-Nignan A, Arrechaga-Estévez D, Beato E, Peña-Acevedo E, Albert A, González-Vera JA, Rodríguez Y, Martín-Martínez M, Valenzuela C, Gutiérrez-Rodríguez M. Cercós P, et al. Int J Mol Sci. 2021 Jan 31;22(3):1419. doi: 10.3390/ijms22031419. Int J Mol Sci. 2021. PMID: 33572566 Free PMC article. Review.
Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2.
de Benito-Bueno A, Socuellamos PG, Merinero YG, Cercos P, Izquierdo C, Daniel-Mozo M, Marín-Olivero I, Perez-Lara A, Gonzalez-Vera JA, Orte A, Albert A, Martin-Martinez M, Gutierrez-Rodriguez M, Valenzuela C. de Benito-Bueno A, et al. Int J Mol Sci. 2022 Aug 15;23(16):9170. doi: 10.3390/ijms23169170. Int J Mol Sci. 2022. PMID: 36012438 Free PMC article.
Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.
Cruz FM, Macías Á, Moreno-Manuel AI, Gutiérrez LK, Vera-Pedrosa ML, Martínez-Carrascoso I, Sánchez Pérez P, Ruiz Robles JM, Bermúdez-Jiménez FJ, Díaz-Agustín A, Martínez de Benito F, Arias-Santiago S, Braza-Boils A, Martín-Martínez M, Gutierrez-Rodríguez M, Bernal JA, Zorio E, Jiménez-Jaimez J, Jalife J. Cruz FM, et al. Among authors: martin martinez m. Circ Res. 2024 Apr 12;134(8):e52-e71. doi: 10.1161/CIRCRESAHA.123.323895. Epub 2024 Mar 18. Circ Res. 2024. PMID: 38497220 Free article.
Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity.
Fernández-Varas B, Manguan-García C, Rodriguez-Centeno J, Mendoza-Lupiáñez L, Calatayud J, Perona R, Martín-Martínez M, Gutierrez-Rodriguez M, Benítez-Buelga C, Sastre L. Fernández-Varas B, et al. Among authors: martin martinez m. Hum Mol Genet. 2024 Apr 18;33(9):818-834. doi: 10.1093/hmg/ddae015. Hum Mol Genet. 2024. PMID: 38641551 Free PMC article.
124 results