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Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists.
Ieremias L, Kaspersen MH, Manandhar A, Schultz-Knudsen K, Vrettou CI, Pokhrel R, Heidtmann CV, Jenkins L, Kanellou C, Marsango S, Li Y, Bräuner-Osborne H, Rexen Ulven E, Milligan G, Ulven T. Ieremias L, et al. Among authors: marsango s. J Med Chem. 2024 Mar 14;67(5):3542-3570. doi: 10.1021/acs.jmedchem.3c01923. Epub 2024 Feb 21. J Med Chem. 2024. PMID: 38381650
PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84.
Kalita M, Park JH, Kuo RC, Hayee S, Marsango S, Straniero V, Alam IS, Rivera-Rodriguez A, Pandrala M, Carlson ML, Reyes ST, Jackson IM, Suigo L, Luo A, Nagy SC, Valoti E, Milligan G, Habte F, Shen B, James ML. Kalita M, et al. Among authors: marsango s. JACS Au. 2023 Dec 1;3(12):3297-3310. doi: 10.1021/jacsau.3c00435. eCollection 2023 Dec 25. JACS Au. 2023. PMID: 38155640 Free PMC article.
Pro-phagocytic function and structural basis of GPR84 signaling.
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C. Zhang X, et al. Among authors: marsango s. Nat Commun. 2023 Sep 14;14(1):5706. doi: 10.1038/s41467-023-41201-0. Nat Commun. 2023. PMID: 37709767 Free PMC article.
Pro-phagocytic function and structural basis of GPR84 signaling.
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C. Zhang X, et al. Among authors: marsango s. Res Sq [Preprint]. 2023 Feb 15:rs.3.rs-2535247. doi: 10.21203/rs.3.rs-2535247/v1. Res Sq. 2023. PMID: 36824923 Free PMC article. Updated. Preprint.
Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists.
Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, Gillespie J, Rajamanickam M, Morrison A, McElroy S, Tikhonova IG, Milligan G, Jamieson AG. Mahindra A, et al. Among authors: marsango s. J Med Chem. 2022 Aug 25;65(16):11270-11290. doi: 10.1021/acs.jmedchem.2c00804. Epub 2022 Aug 10. J Med Chem. 2022. PMID: 35948061 Free PMC article.
Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease.
Scarpa M, Molloy C, Jenkins L, Strellis B, Budgett RF, Hesse S, Dwomoh L, Marsango S, Tejeda GS, Rossi M, Ahmed Z, Milligan G, Hudson BD, Tobin AB, Bradley SJ. Scarpa M, et al. Among authors: marsango s. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2107389118. doi: 10.1073/pnas.2107389118. Proc Natl Acad Sci U S A. 2021. PMID: 34893539 Free PMC article.
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