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Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair.
Antczak MI, Zhang Y, Wang C, Doran J, Naidoo J, Voruganti S, Williams NS, Markowitz SD, Ready JM. Antczak MI, et al. Among authors: markowitz sd. J Med Chem. 2017 May 11;60(9):3979-4001. doi: 10.1021/acs.jmedchem.7b00271. Epub 2017 Apr 25. J Med Chem. 2017. PMID: 28398755 Free PMC article.
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD. Myung SJ, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. doi: 10.1073/pnas.0603235103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880406 Free PMC article.
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD. Yan M, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13. doi: 10.1073/pnas.0902367106. Epub 2009 May 22. Proc Natl Acad Sci U S A. 2009. PMID: 19470469 Free PMC article. Clinical Trial.
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD. Zhang Y, et al. Among authors: markowitz sd. Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. Science. 2015. PMID: 26068857 Free PMC article.
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.
Kim HB, Kim M, Park YS, Park I, Kim T, Yang SY, Cho CJ, Hwang D, Jung JH, Markowitz SD, Hwang SW, Yang SK, Lim DS, Myung SJ. Kim HB, et al. Among authors: markowitz sd. Gastroenterology. 2017 Feb;152(3):616-630. doi: 10.1053/j.gastro.2016.11.005. Epub 2016 Nov 15. Gastroenterology. 2017. PMID: 27864128 Free PMC article.
Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.
Kishore AH, Liang H, Kanchwala M, Xing C, Ganesh T, Akgul Y, Posner B, Ready JM, Markowitz SD, Word RA. Kishore AH, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6427-E6436. doi: 10.1073/pnas.1704945114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716915 Free PMC article.
A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support.
Desai A, Zhang Y, Park Y, Dawson DM, Larusch GA, Kasturi L, Wald D, Ready JM, Gerson SL, Markowitz SD. Desai A, et al. Among authors: markowitz sd. Haematologica. 2018 Jun;103(6):1054-1064. doi: 10.3324/haematol.2017.178376. Epub 2018 Feb 22. Haematologica. 2018. PMID: 29472361 Free PMC article.
268 results