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A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. Chan JF, et al. Among authors: markovitz dm. Cell Rep Med. 2022 Oct 18;3(10):100774. doi: 10.1016/j.xcrm.2022.100774. Epub 2022 Sep 29. Cell Rep Med. 2022. PMID: 36195094 Free PMC article.
Murine colitis is mediated by vimentin.
Mor-Vaknin N, Legendre M, Yu Y, Serezani CH, Garg SK, Jatzek A, Swanson MD, Gonzalez-Hernandez MJ, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Peters-Golden M, Kao JY, Markovitz DM. Mor-Vaknin N, et al. Among authors: markovitz dm. Sci Rep. 2013;3:1045. doi: 10.1038/srep01045. Epub 2013 Jan 9. Sci Rep. 2013. PMID: 23304436 Free PMC article.
Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin.
Covés-Datson EM, Dyall J, DeWald LE, King SR, Dube D, Legendre M, Nelson E, Drews KC, Gross R, Gerhardt DM, Torzewski L, Postnikova E, Liang JY, Ban B, Shetty J, Hensley LE, Jahrling PB, Olinger GG Jr, White JM, Markovitz DM. Covés-Datson EM, et al. Among authors: markovitz dm. PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007595. doi: 10.1371/journal.pntd.0007595. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31356611 Free PMC article.
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo.
Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM. Covés-Datson EM, et al. Among authors: markovitz dm. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2122-2132. doi: 10.1073/pnas.1915152117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932446 Free PMC article.
Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Covés-Datson EM, King SR, Legendre M, Swanson MD, Gupta A, Claes S, Meagher JL, Boonen A, Zhang L, Kalveram B, Raglow Z, Freiberg AN, Prichard M, Stuckey JA, Schols D, Markovitz DM. Covés-Datson EM, et al. Among authors: markovitz dm. Sci Rep. 2021 Jan 12;11(1):656. doi: 10.1038/s41598-020-80577-7. Sci Rep. 2021. PMID: 33436903 Free PMC article.
The Use of Lectins as Tools to Combat SARS-CoV-2.
Martinez D, Amaral D, Markovitz D, Pinto L. Martinez D, et al. Curr Pharm Des. 2021;27(41):4212-4222. doi: 10.2174/1381612827666210830094743. Curr Pharm Des. 2021. PMID: 34459375 Review.
Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection.
Christodoulou I, Rahnama R, Ravich JW, Seo J, Zolov SN, Marple AN, Markovitz DM, Bonifant CL. Christodoulou I, et al. Among authors: markovitz dm. Front Immunol. 2021 Dec 23;12:763460. doi: 10.3389/fimmu.2021.763460. eCollection 2021. Front Immunol. 2021. PMID: 35003077 Free PMC article.
118 results