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Novel staphylococcal glycosyltransferases SdgA and SdgB mediate immunogenicity and protection of virulence-associated cell wall proteins.
Hazenbos WL, Kajihara KK, Vandlen R, Morisaki JH, Lehar SM, Kwakkenbos MJ, Beaumont T, Bakker AQ, Phung Q, Swem LR, Ramakrishnan S, Kim J, Xu M, Shah IM, Diep BA, Sai T, Sebrell A, Khalfin Y, Oh A, Koth C, Lin SJ, Lee BC, Strandh M, Koefoed K, Andersen PS, Spits H, Brown EJ, Tan MW, Mariathasan S. Hazenbos WL, et al. Among authors: mariathasan s. PLoS Pathog. 2013;9(10):e1003653. doi: 10.1371/journal.ppat.1003653. Epub 2013 Oct 10. PLoS Pathog. 2013. PMID: 24130480 Free PMC article. Clinical Trial.
PILRα negatively regulates mouse inflammatory arthritis.
Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, Del Rio M, Lehar S, Asghari V, Lin W, Mariathasan S, DeVoss J, Misaghi S, Balazs M, Sai T, Haley B, Hass PE, Xu M, Ouyang W, Martin F, Lee WP, Zarrin AA. Sun Y, et al. Among authors: mariathasan s. J Immunol. 2014 Jul 15;193(2):860-70. doi: 10.4049/jimmunol.1400045. Epub 2014 Jun 16. J Immunol. 2014. PMID: 24935926
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus.
Lehar SM, Pillow T, Xu M, Staben L, Kajihara KK, Vandlen R, DePalatis L, Raab H, Hazenbos WL, Morisaki JH, Kim J, Park S, Darwish M, Lee BC, Hernandez H, Loyet KM, Lupardus P, Fong R, Yan D, Chalouni C, Luis E, Khalfin Y, Plise E, Cheong J, Lyssikatos JP, Strandh M, Koefoed K, Andersen PS, Flygare JA, Wah Tan M, Brown EJ, Mariathasan S. Lehar SM, et al. Among authors: mariathasan s. Nature. 2015 Nov 19;527(7578):323-8. doi: 10.1038/nature16057. Epub 2015 Nov 4. Nature. 2015. PMID: 26536114
Pharmacokinetics and pharmacodynamics of DSTA4637A: A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus in mice.
Zhou C, Lehar S, Gutierrez J, Rosenberger CM, Ljumanovic N, Dinoso J, Koppada N, Hong K, Baruch A, Carrasco-Triguero M, Saad O, Mariathasan S, Kamath AV. Zhou C, et al. Among authors: mariathasan s. MAbs. 2016 Nov/Dec;8(8):1612-1619. doi: 10.1080/19420862.2016.1229722. Epub 2016 Sep 21. MAbs. 2016. PMID: 27653831 Free PMC article.
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.
Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, Chen J, Wei B, Phillips GD, Xu K, Kozak KR, Mariathasan S, Flygare JA, Pillow TH. Staben LR, et al. Among authors: mariathasan s. Nat Chem. 2016 Dec;8(12):1112-1119. doi: 10.1038/nchem.2635. Epub 2016 Oct 17. Nat Chem. 2016. PMID: 27874860
POPing the fire into the pyrin?
Mariathasan S, Vucic D. Mariathasan S, et al. Biochem J. 2003 Jul 1;373(Pt 1):e1-2. doi: 10.1042/BJ20030304COM. Biochem J. 2003. PMID: 12939166 Free PMC article. Review.
81 results