Margulets V - Search Results

1

Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.

Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, Billia F, Diwan A, Javaheri A, Kirshenbaum LA. Dhingra R, et al. Among authors: margulets v. Circulation. 2022 Sep 20;146(12):934-954. doi: 10.1161/CIRCULATIONAHA.121.058411. Epub 2022 Aug 19. Circulation. 2022. PMID: 35983756 Free PMC article.

2

Bidirectional regulation of nuclear factor-κB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes.

Dhingra R, Gang H, Wang Y, Biala AK, Aviv Y, Margulets V, Tee A, Kirshenbaum LA. Dhingra R, et al. Among authors: margulets v. Circ Heart Fail. 2013 Mar;6(2):335-43. doi: 10.1161/CIRCHEARTFAILURE.112.000061. Epub 2013 Feb 8. Circ Heart Fail. 2013. PMID: 23395931

3

p53 mediates autophagy and cell death by a mechanism contingent on Bnip3.

Wang EY, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum LA. Wang EY, et al. Among authors: margulets v. Hypertension. 2013 Jul;62(1):70-7. doi: 10.1161/HYPERTENSIONAHA.113.01028. Epub 2013 May 6. Hypertension. 2013. PMID: 23648705

4

Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.

Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW 2nd, Kirshenbaum LA. Dhingra R, et al. Among authors: margulets v. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5537-44. doi: 10.1073/pnas.1414665111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489073 Free PMC article.

5

Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin.

Sassone F, Margulets V, Maraschi A, Rodighiero S, Passafaro M, Silani V, Ciammola A, Kirshenbaum LA, Sassone J. Sassone F, et al. Among authors: margulets v. Hum Mol Genet. 2015 Nov 15;24(22):6530-9. doi: 10.1093/hmg/ddv362. Epub 2015 Sep 10. Hum Mol Genet. 2015. PMID: 26358776

6

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival.

Gang H, Dhingra R, Lin J, Hai Y, Aviv Y, Margulets V, Hamedani M, Thanasupawat T, Leygue E, Klonisch T, Davie JR, Kirshenbaum LA. Gang H, et al. Among authors: margulets v. J Cell Biol. 2015 Sep 28;210(7):1101-15. doi: 10.1083/jcb.201504047. J Cell Biol. 2015. PMID: 26416963 Free PMC article.

7

Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes.

Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, Lieberman B, Nepon H, Margulets V, Dhingra R, Kirshenbaum LA. Dhingra A, et al. Among authors: margulets v. Free Radic Biol Med. 2017 Nov;112:411-422. doi: 10.1016/j.freeradbiomed.2017.08.010. Epub 2017 Aug 30. Free Radic Biol Med. 2017. PMID: 28838842

8

Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids.

Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. Yeang C, et al. Among authors: margulets v. Cardiovasc Res. 2019 Jan 1;115(1):179-189. doi: 10.1093/cvr/cvy136. Cardiovasc Res. 2019. PMID: 29850765 Free PMC article.

9

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy.

Dhingra R, Guberman M, Rabinovich-Nikitin I, Gerstein J, Margulets V, Gang H, Madden N, Thliveris J, Kirshenbaum LA. Dhingra R, et al. Among authors: margulets v. Cardiovasc Res. 2020 May 1;116(6):1161-1174. doi: 10.1093/cvr/cvz240. Cardiovasc Res. 2020. PMID: 31566215 Free PMC article.

10

A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.

Amgalan D, Garner TP, Pekson R, Jia XF, Yanamandala M, Paulino V, Liang FG, Corbalan JJ, Lee J, Chen Y, Karagiannis GS, Sanchez LR, Liang H, Narayanagari SR, Mitchell K, Lopez A, Margulets V, Scarlata M, Santulli G, Asnani A, Peterson RT, Hazan RB, Condeelis JS, Oktay MH, Steidl U, Kirshenbaum LA, Gavathiotis E, Kitsis RN. Amgalan D, et al. Among authors: margulets v. Nat Cancer. 2020 Mar;1(3):315-328. doi: 10.1038/s43018-020-0039-1. Epub 2020 Mar 2. Nat Cancer. 2020. PMID: 32776015 Free PMC article.

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