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Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.
Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Herron S, Ikezu S, Ikezu T, Graham SL, Gupta VK, Black KL, Mirzaei M, Butovsky O, Koronyo-Hamaoui M. Shi H, et al. Among authors: margeta ma. Acta Neuropathol Commun. 2022 Sep 8;10(1):136. doi: 10.1186/s40478-022-01439-z. Acta Neuropathol Commun. 2022. PMID: 36076283 Free PMC article.
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma.
Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O. Margeta MA, et al. Immunity. 2022 Sep 13;55(9):1627-1644.e7. doi: 10.1016/j.immuni.2022.07.014. Epub 2022 Aug 16. Immunity. 2022. PMID: 35977543 Free PMC article.
Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease.
Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Yin Z, et al. Among authors: margeta ma. Nat Neurosci. 2023 Jul;26(7):1196-1207. doi: 10.1038/s41593-023-01355-y. Epub 2023 Jun 8. Nat Neurosci. 2023. PMID: 37291336
APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. Yin Z, et al. Among authors: margeta ma. Nat Immunol. 2023 Nov;24(11):1839-1853. doi: 10.1038/s41590-023-01627-6. Epub 2023 Sep 25. Nat Immunol. 2023. PMID: 37749326
23 results