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Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.
Franco I, Margaria JP, De Santis MC, Ranghino A, Monteyne D, Chiaravalli M, Pema M, Campa CC, Ratto E, Gulluni F, Perez-Morga D, Somlo S, Merlo GR, Boletta A, Hirsch E. Franco I, et al. Among authors: margaria jp. J Am Soc Nephrol. 2016 Apr;27(4):1135-44. doi: 10.1681/ASN.2014100967. Epub 2015 Aug 13. J Am Soc Nephrol. 2016. PMID: 26271513 Free PMC article.
Class II PI3K Functions in Cell Biology and Disease.
Gulluni F, De Santis MC, Margaria JP, Martini M, Hirsch E. Gulluni F, et al. Among authors: margaria jp. Trends Cell Biol. 2019 Apr;29(4):339-359. doi: 10.1016/j.tcb.2019.01.001. Epub 2019 Jan 25. Trends Cell Biol. 2019. PMID: 30691999 Review.
Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.
Campa CC, Margaria JP, Derle A, Del Giudice M, De Santis MC, Gozzelino L, Copperi F, Bosia C, Hirsch E. Campa CC, et al. Among authors: margaria jp. Nat Chem Biol. 2018 Aug;14(8):801-810. doi: 10.1038/s41589-018-0086-4. Epub 2018 Jun 18. Nat Chem Biol. 2018. PMID: 29915378 Free article.
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function.
Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E. Franco I, et al. Among authors: margaria jp. Dev Cell. 2014 Mar 31;28(6):647-58. doi: 10.1016/j.devcel.2014.01.022. Dev Cell. 2014. PMID: 24697898 Free PMC article.
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.
De Santis MC, Gozzelino L, Margaria JP, Costamagna A, Ratto E, Gulluni F, Di Gregorio E, Mina E, Lorito N, Bacci M, Lattanzio R, Sala G, Cappello P, Novelli F, Giovannetti E, Vicentini C, Andreani S, Delfino P, Corbo V, Scarpa A, Porporato PE, Morandi A, Hirsch E, Martini M. De Santis MC, et al. Among authors: margaria jp. Gut. 2023 Feb;72(2):360-371. doi: 10.1136/gutjnl-2021-325117. Epub 2022 May 27. Gut. 2023. PMID: 35623884 Free PMC article.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Gulluni F, et al. Among authors: margaria jp. Science. 2021 Dec 10;374(6573):eabk0410. doi: 10.1126/science.abk0410. Epub 2021 Dec 10. Science. 2021. PMID: 34882480 Free PMC article.
Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.
Li H, Prever L, Hsu MY, Lo WT, Margaria JP, De Santis MC, Zanini C, Forni M, Novelli F, Pece S, Di Fiore PP, Porporato PE, Martini M, Belabed H, Nazare M, Haucke V, Gulluni F, Hirsch E. Li H, et al. Among authors: margaria jp. Adv Sci (Weinh). 2022 Mar;9(9):e2103249. doi: 10.1002/advs.202103249. Epub 2022 Jan 31. Adv Sci (Weinh). 2022. PMID: 35098698 Free PMC article.
20 results