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Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.
Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L. Mulero MC, et al. Among authors: margalef p. Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11. Cancer Cell. 2013. PMID: 23850221 Free PMC article.
BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.
Margalef P, Colomer C, Villanueva A, Montagut C, Iglesias M, Bellosillo B, Salazar R, Martínez-Iniesta M, Bigas A, Espinosa L. Margalef P, et al. Sci Signal. 2015 Apr 21;8(373):ra38. doi: 10.1126/scisignal.2005886. Sci Signal. 2015. PMID: 25900832
IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Solé L, González-Farré M, Alonso J, Montagut C, Martinez-Iniesta M, Bertran J, Borràs E, Iglesias M, Sabidó E, Bigas A, Boulton SJ, Espinosa L. Colomer C, et al. Among authors: margalef p. Mol Cell. 2019 Aug 22;75(4):669-682.e5. doi: 10.1016/j.molcel.2019.05.036. Epub 2019 Jul 10. Mol Cell. 2019. PMID: 31302002 Free PMC article.
RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions.
Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H, Goldstone R, Poetsch AR, Boulton SJ. Kotsantis P, et al. Among authors: margalef p. Cell Rep. 2020 Dec 22;33(12):108546. doi: 10.1016/j.celrep.2020.108546. Cell Rep. 2020. PMID: 33357438 Free PMC article.
12 results