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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: marechal x. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.
Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R. Charton J, et al. Among authors: marechal x. Eur J Med Chem. 2014 May 22;79:184-93. doi: 10.1016/j.ejmech.2014.04.009. Epub 2014 Apr 4. Eur J Med Chem. 2014. PMID: 24735644 Free PMC article.
Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Charton J, Gauriot M, Totobenazara J, Hennuyer N, Dumont J, Bosc D, Marechal X, Elbakali J, Herledan A, Wen X, Ronco C, Gras-Masse H, Heninot A, Pottiez V, Landry V, Staels B, Liang WG, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R. Charton J, et al. Among authors: marechal x. Eur J Med Chem. 2015 Jan 27;90:547-67. doi: 10.1016/j.ejmech.2014.12.005. Epub 2014 Dec 4. Eur J Med Chem. 2015. PMID: 25489670 Free PMC article.
From cardiac mitochondrial dysfunction to clinical arrhythmias.
Montaigne D, Maréchal X, Lacroix D, Staels B. Montaigne D, et al. Among authors: marechal x. Int J Cardiol. 2015 Apr 1;184:597-599. doi: 10.1016/j.ijcard.2015.03.012. Epub 2015 Mar 3. Int J Cardiol. 2015. PMID: 25769006 Review. No abstract available.
Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.
Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, Berthier A, Gheeraert C, Piveteau C, Deprez R, Eeckhoute J, Duez H, Lacroix D, Deprez B, Jegou B, Koussa M, Edme JL, Lefebvre P, Staels B. Montaigne D, et al. Among authors: marechal x. Lancet. 2018 Jan 6;391(10115):59-69. doi: 10.1016/S0140-6736(17)32132-3. Epub 2017 Oct 26. Lancet. 2018. PMID: 29107324 Clinical Trial.
Effects of the PPAR-α agonist fenofibrate on acute and short-term consequences of brain ischemia.
Ouk T, Gautier S, Pétrault M, Montaigne D, Maréchal X, Masse I, Devedjian JC, Deplanque D, Bastide M, Nevière R, Duriez P, Staels B, Pasquier F, Leys D, Bordet R. Ouk T, et al. Among authors: marechal x. J Cereb Blood Flow Metab. 2014 Mar;34(3):542-51. doi: 10.1038/jcbfm.2013.233. Epub 2014 Jan 8. J Cereb Blood Flow Metab. 2014. PMID: 24398933 Free PMC article.
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.
Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P. Ploton M, et al. Among authors: marechal x. J Hepatol. 2018 Nov;69(5):1099-1109. doi: 10.1016/j.jhep.2018.06.022. Epub 2018 Jul 5. J Hepatol. 2018. PMID: 29981427 Free article.
65 results