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Page 1
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC. Andersson L, et al. Among authors: mardani i. Eur Heart J. 2021 Nov 14;42(43):4481-4492. doi: 10.1093/eurheartj/ehab412. Eur Heart J. 2021. PMID: 34297830 Free PMC article.
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC. Andersson L, et al. Among authors: mardani i. Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12. Int J Biochem Cell Biol. 2017. PMID: 28811250
Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.
Mardani I, Tomas Dalen K, Drevinge C, Miljanovic A, Ståhlman M, Klevstig M, Scharin Täng M, Fogelstrand P, Levin M, Ekstrand M, Nair S, Redfors B, Omerovic E, Andersson L, Kimmel AR, Borén J, Levin MC. Mardani I, et al. Sci Rep. 2019 May 6;9(1):6909. doi: 10.1038/s41598-019-43335-y. Sci Rep. 2019. PMID: 31061399 Free PMC article.
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.
Klevstig M, Arif M, Mannila M, Svedlund S, Mardani I, Ståhlman M, Andersson L, Lindbom M, Miljanovic A, Franco-Cereceda A, Eriksson P, Jeppsson A, Gan LM, Levin M, Mardinoglu A, Ehrenborg E, Borén J. Klevstig M, et al. Among authors: mardani i. J Mol Cell Cardiol. 2019 Dec;137:1-8. doi: 10.1016/j.yjmcc.2019.09.003. Epub 2019 Sep 15. J Mol Cell Cardiol. 2019. PMID: 31533023 Free article.
Perilipin 5 is protective in the ischemic heart.
Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC. Drevinge C, et al. Among authors: mardani i. Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16. Int J Cardiol. 2016. PMID: 27376234 Free article.
Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
Cinato M, Mardani I, Miljanovic A, Drevinge C, Laudette M, Bollano E, Henricsson M, Tolö J, Bauza Thorbrügge M, Levin M, Lindbom M, Arif M, Pacher P, Andersson L, Olofsson CS, Borén J, Levin MC. Cinato M, et al. Among authors: mardani i. Life Sci Alliance. 2023 Jan 30;6(4):e202201690. doi: 10.26508/lsa.202201690. Print 2023 Apr. Life Sci Alliance. 2023. PMID: 36717246 Free PMC article.