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Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice.
Borowik AK, Lawrence MM, Peelor FF 3rd, Piekarz KM, Crosswhite A, Richardson A, Miller BF, Van Remmen H, Brown JL. Borowik AK, et al. Among authors: lawrence mm. Geroscience. 2024 Jun;46(3):3219-3233. doi: 10.1007/s11357-024-01070-x. Epub 2024 Jan 18. Geroscience. 2024. PMID: 38233728 Free PMC article.
Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy.
Fuqua JD, Lawrence MM, Hettinger ZR, Borowik AK, Brecheen PL, Szczygiel MM, Abbott CB, Peelor FF 3rd, Confides AL, Kinter M, Bodine SC, Dupont-Versteegden EE, Miller BF. Fuqua JD, et al. Among authors: lawrence mm. J Cachexia Sarcopenia Muscle. 2023 Oct;14(5):2076-2089. doi: 10.1002/jcsm.13285. Epub 2023 Jul 14. J Cachexia Sarcopenia Muscle. 2023. PMID: 37448295 Free PMC article.
Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.
Thadathil N, Selvarani R, Mohammed S, Nicklas EH, Tran AL, Kamal M, Luo W, Brown JL, Lawrence MM, Borowik AK, Miller BF, Van Remmen H, Richardson A, Deepa SS. Thadathil N, et al. Among authors: lawrence mm. Aging Cell. 2022 Aug;21(8):e13676. doi: 10.1111/acel.13676. Epub 2022 Jul 23. Aging Cell. 2022. PMID: 35869934 Free PMC article.
22 results