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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Lupi R, et al. Among authors: marchetti p. Diabetes. 2002 May;51(5):1437-42. doi: 10.2337/diabetes.51.5.1437. Diabetes. 2002. PMID: 11978640
Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.
Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S. Lupi R, et al. Among authors: marchetti p. Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. doi: 10.1152/ajpendo.00561.2002. Epub 2003 Nov 18. Am J Physiol Endocrinol Metab. 2004. PMID: 14625208 Free article.
1,444 results