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Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy.
Tsui H, van Kampen SJ, Han SJ, Meraviglia V, van Ham WB, Casini S, van der Kraak P, Vink A, Yin X, Mayr M, Bossu A, Marchal GA, Monshouwer-Kloots J, Eding J, Versteeg D, de Ruiter H, Bezstarosti K, Groeneweg J, Klaasen SJ, van Laake LW, Demmers JAA, Kops GJPL, Mummery CL, van Veen TAB, Remme CA, Bellin M, van Rooij E. Tsui H, et al. Among authors: marchal ga. Sci Transl Med. 2023 Mar 22;15(688):eadd4248. doi: 10.1126/scitranslmed.add4248. Epub 2023 Mar 22. Sci Transl Med. 2023. PMID: 36947592
Differential Sodium Current Remodelling Identifies Distinct Cellular Proarrhythmic Mechanisms in Paroxysmal vs Persistent Atrial Fibrillation.
Casini S, Marchal GA, Kawasaki M, Fabrizi B, Wesselink R, Nariswari FA, Neefs J, van den Berg NWE, Driessen AHG, de Groot JR, Verkerk AO, Remme CA. Casini S, et al. Among authors: marchal ga. Can J Cardiol. 2023 Mar;39(3):277-288. doi: 10.1016/j.cjca.2022.12.023. Epub 2022 Dec 28. Can J Cardiol. 2023. PMID: 36586483 Free article.
Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms.
Biasci V, Santini L, Marchal GA, Hussaini S, Ferrantini C, Coppini R, Loew LM, Luther S, Campione M, Poggesi C, Pavone FS, Cerbai E, Bub G, Sacconi L. Biasci V, et al. Among authors: marchal ga. Basic Res Cardiol. 2022 Apr 29;117(1):25. doi: 10.1007/s00395-022-00933-8. Basic Res Cardiol. 2022. PMID: 35488105 Free PMC article.
Chronically elevated branched chain amino acid levels are pro-arrhythmic.
Portero V, Nicol T, Podliesna S, Marchal GA, Baartscheer A, Casini S, Tadros R, Treur JL, Tanck MWT, Cox IJ, Probert F, Hough TA, Falcone S, Beekman L, Müller-Nurasyid M, Kastenmüller G, Gieger C, Peters A, Kääb S, Sinner MF, Blease A, Verkerk AO, Bezzina CR, Potter PK, Remme CA. Portero V, et al. Among authors: marchal ga. Cardiovasc Res. 2022 Jun 22;118(7):1742-1757. doi: 10.1093/cvr/cvab207. Cardiovasc Res. 2022. PMID: 34142125 Free PMC article.
Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
Marchal GA, Jouni M, Chiang DY, Pérez-Hernández M, Podliesna S, Yu N, Casini S, Potet F, Veerman CC, Klerk M, Lodder EM, Mengarelli I, Guan K, Vanoye CG, Rothenberg E, Charpentier F, Redon R, George AL Jr, Verkerk AO, Bezzina CR, MacRae CA, Burridge PW, Delmar M, Galjart N, Portero V, Remme CA. Marchal GA, et al. Circ Res. 2021 Jul 23;129(3):349-365. doi: 10.1161/CIRCRESAHA.120.318643. Epub 2021 Jun 7. Circ Res. 2021. PMID: 34092082 Free PMC article.
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