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Chronically elevated branched chain amino acid levels are pro-arrhythmic.
Portero V, Nicol T, Podliesna S, Marchal GA, Baartscheer A, Casini S, Tadros R, Treur JL, Tanck MWT, Cox IJ, Probert F, Hough TA, Falcone S, Beekman L, Müller-Nurasyid M, Kastenmüller G, Gieger C, Peters A, Kääb S, Sinner MF, Blease A, Verkerk AO, Bezzina CR, Potter PK, Remme CA. Portero V, et al. Among authors: marchal ga. Cardiovasc Res. 2022 Jun 22;118(7):1742-1757. doi: 10.1093/cvr/cvab207. Cardiovasc Res. 2022. PMID: 34142125 Free PMC article.
A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy.
Rivaud MR, Jansen JA, Postema PG, Nannenberg EA, Mizusawa Y, van der Nagel R, Wolswinkel R, van der Made I, Marchal GA, Rajamani S, Belardinelli L, van Tintelen JP, Tanck MWT, van der Wal AC, de Bakker JMT, van Rijen HV, Creemers EE, Wilde AAM, van den Berg MP, van Veen TAB, Bezzina CR, Remme CA. Rivaud MR, et al. Among authors: marchal ga. Eur Heart J. 2018 Aug 14;39(31):2898-2907. doi: 10.1093/eurheartj/ehy247. Eur Heart J. 2018. PMID: 29718149
Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes.
Casini S, Marchal GA, Kawasaki M, Nariswari FA, Portero V, van den Berg NWE, Guan K, Driessen AHG, Veldkamp MW, Mengarelli I, de Groot JR, Verkerk AO, Remme CA. Casini S, et al. Among authors: marchal ga. Cardiovasc Drugs Ther. 2019 Dec;33(6):649-660. doi: 10.1007/s10557-019-06925-6. Cardiovasc Drugs Ther. 2019. PMID: 31916131 Free PMC article.
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
Rivaud MR, Marchal GA, Wolswinkel R, Jansen JA, van der Made I, Beekman L, Ruiz-Villalba A, Baartscheer A, Rajamani S, Belardinelli L, van Veen TAB, Basso C, Thiene G, Creemers EE, Bezzina CR, Remme CA. Rivaud MR, et al. Among authors: marchal ga. Europace. 2020 Oct 1;22(10):1579-1589. doi: 10.1093/europace/euaa127. Europace. 2020. PMID: 32778883 Free PMC article.
Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.
Marchal GA, Jouni M, Chiang DY, Pérez-Hernández M, Podliesna S, Yu N, Casini S, Potet F, Veerman CC, Klerk M, Lodder EM, Mengarelli I, Guan K, Vanoye CG, Rothenberg E, Charpentier F, Redon R, George AL Jr, Verkerk AO, Bezzina CR, MacRae CA, Burridge PW, Delmar M, Galjart N, Portero V, Remme CA. Marchal GA, et al. Circ Res. 2021 Jul 23;129(3):349-365. doi: 10.1161/CIRCRESAHA.120.318643. Epub 2021 Jun 7. Circ Res. 2021. PMID: 34092082 Free PMC article.
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