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Effects of 17β-HSD2 inhibition in bones on osteoporosis based on an animal rat model.
Müller ST, Pählig S, Merabet A, Abdelsamie AS, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW, Zierau O, Vollmer G. Müller ST, et al. Among authors: marchais oberwinkler s. J Steroid Biochem Mol Biol. 2019 Sep;192:105405. doi: 10.1016/j.jsbmb.2019.105405. Epub 2019 Jun 8. J Steroid Biochem Mol Biol. 2019. PMID: 31185280
17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J. Marchais-Oberwinkler S, et al. J Steroid Biochem Mol Biol. 2011 May;125(1-2):66-82. doi: 10.1016/j.jsbmb.2010.12.013. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193039 Review.
Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
Siebenbuerger L, Hernandez-Olmos V, Abdelsamie AS, Frotscher M, van Koppen CJ, Marchais-Oberwinkler S, Scheuer C, Laschke MW, Menger MD, Boerger C, Hartmann RW. Siebenbuerger L, et al. Among authors: marchais oberwinkler s. J Med Chem. 2018 Dec 13;61(23):10724-10738. doi: 10.1021/acs.jmedchem.8b01373. Epub 2018 Nov 27. J Med Chem. 2018. PMID: 30480443
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
Abdelsamie AS, Herath S, Biskupek Y, Börger C, Siebenbürger L, Salah M, Scheuer C, Marchais-Oberwinkler S, Frotscher M, Pohlemann T, Menger MD, Hartmann RW, Laschke MW, van Koppen CJ. Abdelsamie AS, et al. Among authors: marchais oberwinkler s. J Med Chem. 2019 Feb 14;62(3):1362-1372. doi: 10.1021/acs.jmedchem.8b01493. Epub 2019 Jan 15. J Med Chem. 2019. PMID: 30645111
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
Abdelsamie AS, Salah M, Siebenbürger L, Merabet A, Scheuer C, Frotscher M, Müller ST, Zierau O, Vollmer G, Menger MD, Laschke MW, van Koppen CJ, Marchais-Oberwinkler S, Hartmann RW. Abdelsamie AS, et al. Among authors: marchais oberwinkler s. J Med Chem. 2019 Aug 8;62(15):7289-7301. doi: 10.1021/acs.jmedchem.9b00932. Epub 2019 Jul 25. J Med Chem. 2019. PMID: 31343176
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Frotscher M, Ziegler E, Marchais-Oberwinkler S, Kruchten P, Neugebauer A, Fetzer L, Scherer C, Müller-Vieira U, Messinger J, Thole H, Hartmann RW. Frotscher M, et al. J Med Chem. 2008 Apr 10;51(7):2158-69. doi: 10.1021/jm701447v. Epub 2008 Mar 7. J Med Chem. 2008. PMID: 18324762
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Bey E, Marchais-Oberwinkler S, Kruchten P, Frotscher M, Werth R, Oster A, Algül O, Neugebauer A, Hartmann RW. Bey E, et al. Bioorg Med Chem. 2008 Jun 15;16(12):6423-35. doi: 10.1016/j.bmc.2008.04.073. Epub 2008 May 3. Bioorg Med Chem. 2008. PMID: 18514529
46 results