Mao X - Search Results

1

Small Molecule SARM1 Inhibitors Recapitulate the SARM1^-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.

Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Hughes RO, et al. Among authors: mao x. Cell Rep. 2021 Jan 5;34(1):108588. doi: 10.1016/j.celrep.2020.108588. Cell Rep. 2021. PMID: 33406435 Free PMC article.

2

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD⁺ Cleavage Activity that Promotes Pathological Axonal Degeneration.

Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J. Essuman K, et al. Among authors: mao x. Neuron. 2017 Mar 22;93(6):1334-1343.e5. doi: 10.1016/j.neuron.2017.02.022. Neuron. 2017. PMID: 28334607 Free PMC article.

3

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. Geisler S, et al. Among authors: mao x. J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040. Epub 2019 Jan 14. J Exp Med. 2019. PMID: 30642945 Free PMC article.

4

Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.

Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ, DiAntonio A, Milbrandt J. Wu T, et al. Among authors: mao x. Cell Rep. 2021 Oct 19;37(3):109872. doi: 10.1016/j.celrep.2021.109872. Cell Rep. 2021. PMID: 34686345 Free PMC article.

5

Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.

Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A. Bloom AJ, et al. Among authors: mao x. Mol Neurodegener. 2022 Jan 6;17(1):1. doi: 10.1186/s13024-021-00511-x. Mol Neurodegener. 2022. PMID: 34991663 Free PMC article.

6

Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.

Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Shi Y, et al. Among authors: mao x. Mol Cell. 2022 May 5;82(9):1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007. Epub 2022 Mar 24. Mol Cell. 2022. PMID: 35334231 Free PMC article.

7

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD⁺ depletion.

Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. Sasaki Y, et al. Among authors: mao x. Elife. 2016 Oct 13;5:e19749. doi: 10.7554/eLife.19749. Elife. 2016. PMID: 27735788 Free PMC article.

8

TIR Domain Proteins Are an Ancient Family of NAD⁺-Consuming Enzymes.

Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J. Essuman K, et al. Among authors: mao x. Curr Biol. 2018 Feb 5;28(3):421-430.e4. doi: 10.1016/j.cub.2017.12.024. Epub 2018 Jan 25. Curr Biol. 2018. PMID: 29395922 Free PMC article.

9

Multiple domain interfaces mediate SARM1 autoinhibition.

Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Shen C, et al. Among authors: mao x. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2023151118. doi: 10.1073/pnas.2023151118. Proc Natl Acad Sci U S A. 2021. PMID: 33468661 Free PMC article.

10

Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity.

Brace EJ, Essuman K, Mao X, Palucki J, Sasaki Y, Milbrandt J, DiAntonio A. Brace EJ, et al. Among authors: mao x. PLoS Genet. 2022 Jun 23;18(6):e1010246. doi: 10.1371/journal.pgen.1010246. eCollection 2022 Jun. PLoS Genet. 2022. PMID: 35737728 Free PMC article.

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