In vitro and in vivo metabolism of psilocybin's active metabolite psilocin.
Thomann J, Kolaczynska KE, Stoeckmann OV, Rudin D, Vizeli P, Hoener MC, Pryce CR, Vollenweider FX, Liechti ME, Duthaler U.
Thomann J, et al.
Front Pharmacol. 2024 Apr 29;15:1391689. doi: 10.3389/fphar.2024.1391689. eCollection 2024.
Front Pharmacol. 2024.
PMID: 38741590
Free PMC article.
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), and UDP-glucuronosyltransferase (UGT). In vivo, metabolism was examined using male C57BL/6J mice and human plasma samples. ...
Metabolism studies were performed using human liver microsomes (HLM), cytochrome P450 (CYP) enzymes, monoamine oxidase (MAO), …